| Literature DB >> 7699997 |
C E Whitworth1, S Fleming, A D Cumming, J J Morton, N J Burns, B C Williams, J J Mullins.
Abstract
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.Entities:
Mesh：
Substances：
Year: 1994 PMID： 7699997 DOI： 10.1038/ki.1994.437
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612