| Literature DB >> 7699706 |
K Lackey1, J M Besterman, W Fletcher, P Leitner, B Morton, D D Sternbach.
Abstract
Substituted 8-ethyl-2-(2-oxo-1,2-dihydroindol-3-ylidene)-8-hydroxy-2,3,5,8- tetrahydro-6-oxa-3a-azacyclopenta[b]naphthalene-1,4,7-triones were synthesized and evaluated as topoisomerase I inhibitors in an in vitro cleavable complex assay. The activity of these compounds may be attributed to their rigid, planar geometry, and an attempt was made to correlate the SAR in this series to known attributes of camptothecin.Entities:
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Year: 1995 PMID： 7699706 DOI： 10.1021/jm00006a008
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446