Literature DB >> 7698191

Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist.

E E Ladenheim1, J E Taylor, D H Coy, T H Moran.   

Abstract

The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

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Year:  1994        PMID： 7698191     DOI： 10.1016/0014-2999(94)90291-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  Insights into bombesin receptors and ligands: Highlighting recent advances.

Authors:  Irene Ramos-Álvarez; Paola Moreno; Samuel A Mantey; Taichi Nakamura; Bernardo Nuche-Berenguer; Terry W Moody; David H Coy; Robert T Jensen
Journal:  Peptides       Date:  2015-05-11       Impact factor: 3.750

2.  Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity.

Authors:  Gabriela Silva Monteiro Paula; Luana Lopes Souza; Adriana Cabanelas; Flavia Fonseca Bloise; Valéria Mello-Coelho; Etsuko Wada; Tania Maria Ortiga-Carvalho; Karen Jesus Oliveira; Carmen Cabanelas Pazos-Moura
Journal:  J Physiol       Date:  2010-03-08       Impact factor: 5.182

3.  Bicarbonate and fluid secretion evoked by cholecystokinin, bombesin and acetylcholine in isolated guinea-pig pancreatic ducts.

Authors:  G Szalmay; G Varga; F Kajiyama; X S Yang; T F Lang; R M Case; M C Steward
Journal:  J Physiol       Date:  2001-09-15       Impact factor: 5.182

4.  Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons.

Authors:  Anthony N van den Pol; Yang Yao; Li-Ying Fu; Kylie Foo; Hao Huang; Roberto Coppari; Bradford B Lowell; Christian Broberger
Journal:  J Neurosci       Date:  2009-04-08       Impact factor: 6.167

5.  Functional properties of two bombesin-like peptide receptors revealed by the analysis of mice lacking neuromedin B receptor.

Authors:  H Ohki-Hamazaki; Y Sakai; K Kamata; H Ogura; S Okuyama; K Watase; K Yamada; K Wada
Journal:  J Neurosci       Date:  1999-02-01       Impact factor: 6.167

Review 6.  International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.

Authors:  R T Jensen; J F Battey; E R Spindel; R V Benya
Journal:  Pharmacol Rev       Date:  2007-11-30       Impact factor: 25.468

7.  Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides.

Authors:  Ellen E Ladenheim; Susan Knipp
Journal:  Physiol Behav       Date:  2007-02-08

8.  Neuromedin B and Its Receptor: Gene Cloning, Tissue Distribution and Expression Levels of the Reproductive Axis in Pigs.

Authors:  Zhiyu Ma; Juan Su; Tingting Guo; Mengmeng Jin; Xiang Li; Zhihai Lei; Yuanlong Hou; Xiaoliang Li; Cuicui Jia; Zheng Zhang; Ejlal Ahmed
Journal:  PLoS One       Date:  2016-03-24       Impact factor: 3.240
  8 in total

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