OBJECTIVE: To determine factors that might be associated with the development of Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS: This cross-sectional prevalence study examined neurological function and bone density in matched groups of neuropathic diabetic patients with and without radiological evidence of Charcot neuroarthropathy. RESULTS: Patients with Charcot neuroarthropathy had a global impairment of neurological function that was significantly greater than that of otherwise matched non-Charcot neuropathic patients. All 17 Charcot patients had evidence of autonomic neuropathy compared with 10 of the control subjects (P = 0.03). The Charcot patients had evidence of reduced bone density in the lower limbs compared with the neuropathic control subjects (P = 0.009), but relatively preserved bone density in the spine (P = 0.4 vs. control subjects). CONCLUSIONS: We conclude that minor trauma in diabetic patients with peripheral neuropathy might result in a fracture in those with a reduced bone density and thus trigger the development of Charcot neuroarthropathy.
OBJECTIVE: To determine factors that might be associated with the development of Charcot neuroarthropathy. RESEARCH DESIGN AND METHODS: This cross-sectional prevalence study examined neurological function and bone density in matched groups of neuropathic diabeticpatients with and without radiological evidence of Charcot neuroarthropathy. RESULTS:Patients with Charcot neuroarthropathy had a global impairment of neurological function that was significantly greater than that of otherwise matched non-Charcot neuropathicpatients. All 17 Charcot patients had evidence of autonomic neuropathy compared with 10 of the control subjects (P = 0.03). The Charcot patients had evidence of reduced bone density in the lower limbs compared with the neuropathic control subjects (P = 0.009), but relatively preserved bone density in the spine (P = 0.4 vs. control subjects). CONCLUSIONS: We conclude that minor trauma in diabeticpatients with peripheral neuropathy might result in a fracture in those with a reduced bone density and thus trigger the development of Charcot neuroarthropathy.
Authors: David R Sinacore; Mary K Hastings; Kathryn L Bohnert; Faye A Fielder; Dennis T Villareal; Vilray P Blair; Jeffrey E Johnson Journal: Phys Ther Date: 2008-09-18
Authors: Paul K Commean; Kirk E Smith; Charles F Hildebolt; Kathryn L Bohnert; David R Sinacore; Fred W Prior Journal: J Clin Densitom Date: 2017-06-28 Impact factor: 2.617
Authors: Paul K Commean; Jared A Kennedy; Karen A Bahow; Charles F Hildebolt; Lu Liu; Kirk E Smith; Mary K Hastings; Tao Ju; Fred W Prior; David R Sinacore Journal: J Clin Densitom Date: 2011-07-01 Impact factor: 2.617