Literature DB >> 769772

Double blind trial of L-dopa in chronic schizophrenia.

F H Buchanan, R V Parton, J W Warren, E P Baker.   

Abstract

A double blind study in 28 patients with chronic schizophrenia was carried out comparing L-dopa (up to 1250 mgm daily) with placebo (both groups continuing to receive regular neuroleptic medication) over a six week period. Assessments by the psychiatrists and psychologist using Rockland and Pollin Rating Scale showed differential improvement of insignificant proportions but the nurse's ratings showed clearly significant improvement in the subject group.

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Year:  1975        PMID: 769772     DOI: 10.3109/00048677509159861

Source DB:  PubMed          Journal:  Aust N Z J Psychiatry        ISSN: 0004-8674            Impact factor:   5.744


  3 in total

Review 1.  Negative symptoms: psychopathological models.

Authors:  J Ananth; A Djenderdjian; P Shamasunder; J Costa; J Herrera; J Sramek
Journal:  J Psychiatry Neurosci       Date:  1991-03       Impact factor: 6.186

2.  Dopamine agonists for negative symptoms in schizophrenia.

Authors:  D J King
Journal:  Br J Clin Pharmacol       Date:  1978-12       Impact factor: 4.335

Review 3.  A meta-analysis of the response to chronic L-dopa in patients with schizophrenia: therapeutic and heuristic implications.

Authors:  George E Jaskiw; Anand P Popli
Journal:  Psychopharmacology (Berl)       Date:  2003-12-11       Impact factor: 4.530

  3 in total

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