| Literature DB >> 7697499 |
C Guyomard1, J Bouffechoux, J Bourniche, C Chesné.
Abstract
A cell kit named PREDISAFE based on the use of confluent rabbit fibroblastic cells has been designed to predict eye irritancy of cosmetic raw materials and formulations. The kit can be stored for a few days and/or shipped at room temperature. Cytotoxicity was estimated after 1 min or 15 min contact with test compounds using the neutral red release assay. For the 84 products tested, IC50 values gave intervals similar to classes defined from the Draize test, i.e., mild, moderate, severe and extreme irritancy.Entities:
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Year: 1994 PMID： 7697499 DOI： 10.1007/bf00755785
Source DB: PubMed Journal: Cell Biol Toxicol ISSN： 0742-2091 Impact factor: 6.691