Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Tumor suppression. Lessons in p16 from phylum Falconium.

Literature DB >> 7697342

Tumor suppression. Lessons in p16 from phylum Falconium.

Abstract

Increasingly, biochemical and genetic evidence indicates that mutations in the gene encoding p16, an inhibitor of cyclin-dependent kinases, may play a role in some forms of hereditary and sporadic tumors.

Entities: Disease Gene

Mesh：

Substances：

Year: 1995 PMID： 7697342 DOI： 10.1016/s0960-9822(95)00009-1

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

Keyword Cloud
Cited

8 in total

1. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins.

Authors: J Hermanns; A Schulze; P Jansen-Db1urr; J A Kleinschmidt; R Schmidt; H zur Hausen
Journal: J Virol Date: 1997-08 Impact factor: 5.103

2. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.

Authors: E Hara; R Smith; D Parry; H Tahara; S Stone; G Peters
Journal: Mol Cell Biol Date: 1996-03 Impact factor: 4.272

3. Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.

Authors: D Parry; G Peters
Journal: Mol Cell Biol Date: 1996-07 Impact factor: 4.272

4. Growth suppression by p16ink4 requires functional retinoblastoma protein.

Authors: R H Medema; R E Herrera; F Lam; R A Weinberg
Journal: Proc Natl Acad Sci U S A Date: 1995-07-03 Impact factor: 11.205

5. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

Authors: T Suzuki; S Kitao; H Matsushime; M Yoshida
Journal: EMBO J Date: 1996-04-01 Impact factor: 11.598

Tumor suppression. Lessons in p16 from phylum Falconium.

1. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins.

2. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.

3. Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.

4. Growth suppression by p16ink4 requires functional retinoblastoma protein.

5. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

6. Absence of deletions but frequent loss of expression of p16INK4 in human ovarian tumours.

7. Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein.

8. Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells.