Literature DB >> 7696590

Molecular cloning and expression of a human heart inward rectifier potassium channel.

K F Raab-Graham1, C M Radeke, C A Vandenberg.   

Abstract

We have isolated a cDNA encoding an inwardly rectifying K+ channel (HH-IRK1) from human heart. The cDNA codes for a 427-amino acid protein, with two putative transmembrane domains and an H5 region. The primary structure of HH-IRK1 is homologous to that of the IRK1 channel cloned from a mouse macrophage-like cell line. Functional expression in Xenopus oocytes showed that HH-IRK1 is a K+ channel with strong inward rectification, blocked by extracellular Ba2+ and Cs+, and with a single-channel conductance of 30 pS. Northern analysis showed HH-IRK1 transcripts in human heart, brain, skeletal muscle, placenta, lung and kidney. HH-IRK1 was mapped to human chromosome 17.

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Year:  1994        PMID： 7696590     DOI： 10.1097/00001756-199412000-00024

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  26 in total

1.  Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.

Authors:  Regina Preisig-Müller; Günter Schlichthörl; Tobias Goerge; Steffen Heinen; Andrea Brüggemann; Sindhu Rajan; Christian Derst; Rüdiger W Veh; Jürgen Daut
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 2.  Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review.

Authors:  Bikash R Pattnaik; Matti P Asuma; Ryan Spott; De-Ann M Pillers
Journal:  Mol Genet Metab       Date:  2011-10-19       Impact factor: 4.797

3.  Inward rectifier potassium currents in mammalian skeletal muscle fibres.

Authors:  Marino DiFranco; Carl Yu; Marbella Quiñonez; Julio L Vergara
Journal:  J Physiol       Date:  2015-02-04       Impact factor: 5.182

4.  Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells.

Authors:  De-Yong Zhang; Yan-Hui Zhang; Hai-Ying Sun; Chu-Pak Lau; Gui-Rong Li
Journal:  Br J Pharmacol       Date:  2011-11       Impact factor: 8.739

5.  In vivo and in vitro functional characterization of Andersen's syndrome mutations.

Authors:  Saïd Bendahhou; Emmanuel Fournier; Damien Sternberg; Guillaume Bassez; Alain Furby; Carole Sereni; Matthew R Donaldson; Marie-Madeleine Larroque; Bertrand Fontaine; Jacques Barhanin
Journal:  J Physiol       Date:  2005-04-14       Impact factor: 5.182

6.  The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells.

Authors:  Xiao-Hua Zhang; Man-Wen Jin; Hai-Ying Sun; Shetuan Zhang; Gui-Rong Li
Journal:  Br J Pharmacol       Date:  2010-10       Impact factor: 8.739

7.  Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity.

Authors:  Gernot Schram; Peter Melnyk; Marc Pourrier; Zhiguo Wang; Stanley Nattel
Journal:  J Physiol       Date:  2002-10-15       Impact factor: 5.182

8.  Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).

Authors:  Martin Tristani-Firouzi; Judy L Jensen; Matthew R Donaldson; Valeria Sansone; Giovanni Meola; Angelika Hahn; Said Bendahhou; Hubert Kwiecinski; Anna Fidzianska; Nikki Plaster; Ying-Hui Fu; Louis J Ptacek; Rabi Tawil
Journal:  J Clin Invest       Date:  2002-08       Impact factor: 14.808

Review 9.  Cardiac strong inward rectifier potassium channels.

Authors:  Justus M B Anumonwo; Anatoli N Lopatin
Journal:  J Mol Cell Cardiol       Date:  2009-08-22       Impact factor: 5.000

10.  K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks.

Authors:  Karin Jurkat-Rott; Marc-André Weber; Michael Fauler; Xiu-Hai Guo; Boris D Holzherr; Agathe Paczulla; Nikolai Nordsborg; Wolfgang Joechle; Frank Lehmann-Horn
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-18       Impact factor: 11.205
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