Literature DB >> 7695905

The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity.

P F Chapman1, B G Frenguelli, A Smith, C M Chen, A J Silva.   

Abstract

The alpha-Ca2+/calmodulin kinase II (alpha CaMKII) is required for long-term potentiation in the CA1 region of the hippocampus. Here, we report that this kinase also has a crucial role in presynaptic plasticity. Paired-pulse facilitation is blunted in the CA1 region of mice heterozygous for a targeted mutation of alpha CaMKII, confirming that this kinase can promote neurotransmitter release. Unexpectedly, field and whole-cell recordings of posttetanic potentiation show that the synaptic responses of mutants are larger than those of controls, indicating that alpha CaMKII can also inhibit transmitter release immediately after tetanic stimulation. Thus, alpha CaMKII has the capacity either to potentiate or to depress excitatory synaptic transmission depending on the pattern of presynaptic activation.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7695905     DOI： 10.1016/0896-6273(95)90315-1

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  39 in total

1.  Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.

Authors:  K P Giese; J F Storm; D Reuter; N B Fedorov; L R Shao; T Leicher; O Pongs; A J Silva
Journal:  Learn Mem       Date:  1998 Sep-Oct       Impact factor: 2.460

2.  Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release.

Authors:  M Okada; D J Nutt; T Murakami; G Zhu; A Kamata; Y Kawata; S Kaneko
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

3.  Phosphorylation of the synaptic protein interaction site on N-type calcium channels inhibits interactions with SNARE proteins.

Authors:  C T Yokoyama; Z H Sheng; W A Catterall
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

4.  Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase.

Authors:  E Thiels; N N Urban; G R Gonzalez-Burgos; B I Kanterewicz; G Barrionuevo; C T Chu; T D Oury; E Klann
Journal:  J Neurosci       Date:  2000-10-15       Impact factor: 6.167

5.  Frequency-dependent inactivation of mammalian A-type K+ channel KV1.4 regulated by Ca2+/calmodulin-dependent protein kinase.

Authors:  J Roeper; C Lorra; O Pongs
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

Review 6.  Short-term presynaptic plasticity.

Authors:  Wade G Regehr
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-07-01       Impact factor: 10.005

7.  Localization of alpha type II calcium calmodulin-dependent protein kinase at glutamatergic but not gamma-aminobutyric acid (GABAergic) synapses in thalamus and cerebral cortex.

Authors:  X B Liu; E G Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

8.  The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster.

Authors:  Elena A Kuklin; Stephen Alkins; Baskar Bakthavachalu; Maria C Genco; Indulekha Sudhakaran; K Vijay Raghavan; Mani Ramaswami; Leslie C Griffith
Journal:  J Neurosci       Date:  2017-09-27       Impact factor: 6.167

9.  Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release.

Authors:  D Debanne; N C Guérineau; B H Gähwiler; S M Thompson
Journal:  J Physiol       Date:  1996-02-15       Impact factor: 5.182

10.  Ca2+-independent activation of Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain of CaV2.1 calcium channels.

Authors:  Venkat G Magupalli; Sumiko Mochida; Jin Yan; Xin Jiang; Ruth E Westenbroek; Angus C Nairn; Todd Scheuer; William A Catterall
Journal:  J Biol Chem       Date:  2012-12-19       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.