Literature DB >> 7695645

Presence of both A1 and A2a adenosine receptors in human cells and their interaction.

A H Ahmed1, K A Jacobson, J Kim, L A Heppel.   

Abstract

We have obtained pharmacological evidence for the expression of both A1- (inhibitory) and A2a- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The A1 receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine.

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Year:  1995        PMID： 7695645      PMCID： PMC5553076          DOI： 10.1006/bbrc.1995.1416

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells.

Authors:  D van Calker; M Müller; B Hamprecht
Journal:  J Neurochem       Date:  1979-11       Impact factor: 5.372

2.  Distinct pathways of desensitization of A1- and A2-adenosine receptors in DDT1 MF-2 cells.

Authors:  V Ramkumar; M E Olah; K A Jacobson; G L Stiles
Journal:  Mol Pharmacol       Date:  1991-11       Impact factor: 4.436

3.  G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.

Authors:  P J Casey; M P Graziano; A G Gilman
Journal:  Biochemistry       Date:  1989-01-24       Impact factor: 3.162

4.  Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.

Authors:  J Inglese; L M Luttrell; J A Iñiguez-Lluhi; K Touhara; W J Koch; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

5.  Adenosine receptor activation in quiescent Swiss 3T3 cells. Enhancement of cAMP levels, DNA synthesis and cell division.

Authors:  E Rozengurt
Journal:  Exp Cell Res       Date:  1982-05       Impact factor: 3.905

6.  A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.

Authors:  D J Wang; N N Huang; E J Heller; L A Heppel
Journal:  J Biol Chem       Date:  1994-06-17       Impact factor: 5.157

7.  Stimulation of aged human lung fibroblasts by extracellular ATP via suppression of arachidonate metabolism.

Authors:  N N Huang; D J Wang; L A Heppel
Journal:  J Biol Chem       Date:  1993-05-25       Impact factor: 5.157

8.  Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.

Authors:  V Ramkumar; W W Barrington; K A Jacobson; G L Stiles
Journal:  Mol Pharmacol       Date:  1990-02       Impact factor: 4.436

9.  Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes.

Authors:  R F Bruns; J H Fergus; E W Badger; J A Bristol; L A Santay; J D Hartman; S J Hays; C C Huang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-01       Impact factor: 3.000

10.  Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature.

Authors:  J Vilcek; E A Havell
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205
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  4 in total

Review 1.  Adenosine receptors and asthma in humans.

Authors:  C N Wilson
Journal:  Br J Pharmacol       Date:  2008-10       Impact factor: 8.739

2.  Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors.

Authors:  M Carmen Montesinos; Avani Desai; Jiang-Fan Chen; Herman Yee; Michael A Schwarzschild; J Stephen Fink; Bruce N Cronstein
Journal:  Am J Pathol       Date:  2002-06       Impact factor: 4.307

3.  Adenosine receptors and fibrosis: a translational review.

Authors:  Bruce N Cronstein
Journal:  F1000 Biol Rep       Date:  2011-10-03

4.  Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors.

Authors:  M C Montesinos; P Gadangi; M Longaker; J Sung; J Levine; D Nilsen; J Reibman; M Li; C K Jiang; R Hirschhorn; P A Recht; E Ostad; R I Levin; B N Cronstein
Journal:  J Exp Med       Date:  1997-11-03       Impact factor: 14.307
  4 in total

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