Literature DB >> 7695603

Transgenic mice overexpressing human copper/zinc-superoxide dismutase (Cu/Zn SOD) are not resistant to endotoxic shock.

S de Vos1, C J Epstein, E Carlson, S K Cho, H P Koeffler.   

Abstract

Tumor necrosis factor is a key mediator of the septic shock syndrome, and its secretion by monocytes is induced by endotoxin. Increasing evidence exists that the release of oxygen-derived free radicals by polymorphonuclear cells plays a central role in tumor necrosis factor toxicity. Superoxide dismutases scavenge oxygen-derived free radicals and appear to be excellent candidates to provide protection against tumor-necrosis-factor -mediated cytotoxicity. In this study, we have found that transgenic mice overexpressing the human gene for CuZn SOD are not protected against experimentally induced endotoxemia.

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Year:  1995        PMID： 7695603     DOI： 10.1006/bbrc.1995.1370

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase.

Authors:  M Peled-Kamar; J Lotem; I Wirguin; L Weiner; A Hermalin; Y Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

2.  Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

Authors:  O Bar-Peled; E Korkotian; M Segal; Y Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

Review 3.  Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.

Authors:  Xin Gen Lei; Jian-Hong Zhu; Wen-Hsing Cheng; Yongping Bao; Ye-Shih Ho; Amit R Reddi; Arne Holmgren; Elias S J Arnér
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312

4.  Effect of SOD-1 over-expression on myocardial function during resuscitated murine septic shock.

Authors:  Katja Baumgart; Vladislava Simkova; Florian Wagner; Sandra Weber; Michael Georgieff; Peter Radermacher; Gerd Albuszies; Eberhard Barth
Journal:  Intensive Care Med       Date:  2008-10-15       Impact factor: 17.440

5.  Rapid fluorescence in situ hybridization on interphasic nuclei to discriminate between homozygous and heterozygous transgenic mice.

Authors:  D Paris; K Toyama; A Mégarbané; P M Casanova; P M Sinet; J London
Journal:  Transgenic Res       Date:  1996-11       Impact factor: 2.788

6.  Decreased pulmonary extracellular superoxide dismutase during systemic inflammation.

Authors:  Junji Ueda; Marlene E Starr; Hitoshi Takahashi; Jie Du; Ling Yi Chang; James D Crapo; B Mark Evers; Hiroshi Saito
Journal:  Free Radic Biol Med       Date:  2008-06-24       Impact factor: 7.376

7.  Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock.

Authors:  Jean Charchaflieh; Georges I Labaze; Pulsar Li; Holly Van Remmen; Haekyung Lee; Helen Stutz; Arlan Richardson; Asher Emanuel; Ming Zhang
Journal:  J Inflamm Res       Date:  2012-07-24

8.  Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction.

Authors:  Georg Singer; Karen Y Stokes; D Neil Granger
Journal:  Inflamm Res       Date:  2012-10-18       Impact factor: 4.575

9.  Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.

Authors:  M Peled-Kamar; J Lotem; E Okon; L Sachs; Y Groner
Journal:  EMBO J       Date:  1995-10-16       Impact factor: 11.598
  9 in total

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