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Literature DB >> 7695282

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.

Abstract

In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.

Entities: Chemical Species

Mesh：

Substances：
2,2'-Dipyridyl

Year: 1994 PMID： 7695282 PMCID： PMC188306 DOI： 10.1128/AAC.38.12.2908

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

Review 1. The need for new drugs in the treatment and control of leprosy.

Authors: R J Baker
Journal: Int J Lepr Other Mycobact Dis Date: 1990-03

2. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides.

Authors: M A de Zwart; H van der Goot; H Timmerman
Journal: J Med Chem Date: 1988-04 Impact factor: 7.446

3. Effect of brodimoprim on Mycobacterium leprae in vitro and in mouse foot-pads.

Authors: A M Dhople; I Ortega; J K Seydel; G D Gardner
Journal: Indian J Lepr Date: 1990 Jan-Mar

4. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines.

Authors: M A de Zwart; H van der Goot; H Timmerman
Journal: J Med Chem Date: 1989-02 Impact factor: 7.446

1. Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deferoxamine.

Authors: S L Newman; L Gootee; V Stroobant; H van der Goot; J R Boelaert
Journal: Antimicrob Agents Chemother Date: 1995-08 Impact factor: 5.191

1 in total

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.

Review 1. The need for new drugs in the treatment and control of leprosy.

2. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 1. Amides.

3. Effect of brodimoprim on Mycobacterium leprae in vitro and in mouse foot-pads.

4. Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines.

5. Autoradiographic and metabolic studies of Mycobacterium leprae.

6. In vitro growth of Mycobacterium lepraemurium, an obligate intracellular microbe.

Review 7. Drug resistance in leprosy--a review.

8. Limited in vitro multiplication of Mycobacterium leprae.

9. Influence of membrane composition of various parasites on the inhibitory activity of a series of bipyridyl analogues.

10. Evaluation of a bioluminescence assay for rapid antimicrobial susceptibility testing of mycobacteria.

1. Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deferoxamine.