Literature DB >> 7695227

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

S G Younkin.   

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Year:  1995        PMID： 7695227     DOI： 10.1002/ana.410370303

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


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  69 in total

1.  Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

Authors:  K Fassbender; M Simons; C Bergmann; M Stroick; D Lutjohann; P Keller; H Runz; S Kuhl; T Bertsch; K von Bergmann; M Hennerici; K Beyreuther; T Hartmann
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

2.  Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.

Authors:  Asad Jan; Dean M Hartley; Hilal A Lashuel
Journal:  Nat Protoc       Date:  2010-06-03       Impact factor: 13.491

3.  Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments.

Authors:  Lei Gu; Sam Ngo; Zhefeng Guo
Journal:  J Biol Chem       Date:  2012-01-25       Impact factor: 5.157

4.  Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.

Authors:  Preeti J Khandelwal; Sonya B Dumanis; Alexander M Herman; G William Rebeck; Charbel E-H Moussa
Journal:  Mol Cell Neurosci       Date:  2011-09-14       Impact factor: 4.314

5.  Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors.

Authors:  F Huang; M Buttini; T Wyss-Coray; L McConlogue; T Kodama; R E Pitas; L Mucke
Journal:  Am J Pathol       Date:  1999-11       Impact factor: 4.307

Review 6.  The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.

Authors:  Sam Gandy
Journal:  J Clin Invest       Date:  2005-05       Impact factor: 14.808

7.  Arginine and disordered amyloid-β peptide structures: molecular level insights into the toxicity in Alzheimer's disease.

Authors:  Orkid Coskuner; Olivia Wise-Scira
Journal:  ACS Chem Neurosci       Date:  2013-10-08       Impact factor: 4.418

8.  Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

Authors:  Juliette Janson; Susanna Eketjäll; Karin Tunblad; Fredrik Jeppsson; Stefan Von Berg; Camilla Niva; Ann-Cathrin Radesäter; Johanna Fälting; Sandra A G Visser
Journal:  Pharm Res       Date:  2013-10-03       Impact factor: 4.200

9.  Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.

Authors:  Charbel E-H Moussa
Journal:  J Mol Neurosci       Date:  2008-06-17       Impact factor: 3.444

10.  Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.

Authors:  D Giulian; L J Haverkamp; J H Yu; W Karshin; D Tom; J Li; J Kirkpatrick; L M Kuo; A E Roher
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167
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