OBJECTIVE: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. METHOD: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first-degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. RESULTS: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. CONCLUSIONS: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
OBJECTIVE: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. METHOD: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first-degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. RESULTS: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. CONCLUSIONS: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
Authors: Roxann Roberson-Nay; Donald F Klein; Rachel G Klein; Salvatore Mannuzza; John L Moulton; Mary Guardino; Daniel S Pine Journal: Biol Psychiatry Date: 2010-02-20 Impact factor: 13.382
Authors: N K Leibold; D L A van den Hove; W Viechtbauer; G F Buchanan; L Goossens; I Lange; I Knuts; K P Lesch; H W M Steinbusch; K R J Schruers Journal: Transl Psychiatry Date: 2016-09-06 Impact factor: 6.222