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Literature DB >> 7694457

Recombinant cytokines and pulmonary host defense.

Abstract

The recent discovery of several cytokines and their purification using recombinant DNA technology has uncovered their role as critical factors in pulmonary host defense. The importance of tumor necrosis factor, interferon-gamma, and granulocyte-colony stimulating factor in lung infections was first elucidated in animal models and has been confirmed with neutralization studies. This article reviews these three cytokines, their recent use in human subjects, and their potential use in the future.

Entities: Disease Gene Species

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Year: 1993 PMID： 7694457 DOI： 10.1097/00000441-199311000-00012

Source DB: PubMed Journal: Am J Med Sci ISSN： 0002-9629 Impact factor: 2.378

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Cited

13 in total

1. Intrapulmonary delivery of tumor necrosis factor agonist peptide augments host defense in murine gram-negative bacterial pneumonia.

Authors: L L Laichalk; K A Bucknell; G B Huffnagle; J M Wilkowski; T A Moore; R J Romanelli; T J Standiford
Journal: Infect Immun Date: 1998-06 Impact factor: 3.441

2. The pneumococcus: host-organism interactions and their implications for immunotherapy and immunoprophylaxis.

Authors: F E Perry; J R Catterall
Journal: Thorax Date: 1994-10 Impact factor: 9.139

3. Divergent role of gamma interferon in a murine model of pulmonary versus systemic Klebsiella pneumoniae infection.

Authors: Thomas A Moore; Michelle L Perry; Andrew G Getsoian; Michael W Newstead; Theodore J Standiford
Journal: Infect Immun Date: 2002-11 Impact factor: 3.441

4. Surfactant protein D enhances phagocytosis and killing of unencapsulated phase variants of Klebsiella pneumoniae.

Authors: I Ofek; A Mesika; M Kalina; Y Keisari; R Podschun; H Sahly; D Chang; D McGregor; E Crouch
Journal: Infect Immun Date: 2001-01 Impact factor: 3.441

5. Intrapulmonary concentrations of inflammatory cytokines in a mouse model of chronic respiratory infection caused by Pseudomonas aeruginosa.

Authors: K Yanagihara; K Tomono; M Kuroki; Y Kaneko; T Sawai; H Ohno; Y Miyazaki; Y Higashiyama; S Maesaki; J Kadota; S Kohno
Journal: Clin Exp Immunol Date: 2000-10 Impact factor: 4.330

Recombinant cytokines and pulmonary host defense.

1. Intrapulmonary delivery of tumor necrosis factor agonist peptide augments host defense in murine gram-negative bacterial pneumonia.

2. The pneumococcus: host-organism interactions and their implications for immunotherapy and immunoprophylaxis.

3. Divergent role of gamma interferon in a murine model of pulmonary versus systemic Klebsiella pneumoniae infection.

4. Surfactant protein D enhances phagocytosis and killing of unencapsulated phase variants of Klebsiella pneumoniae.

5. Intrapulmonary concentrations of inflammatory cytokines in a mouse model of chronic respiratory infection caused by Pseudomonas aeruginosa.

Review 6. Role of cytokines in pulmonary antimicrobial host defense.

7. Nitric oxide is required for effective innate immunity against Klebsiella pneumoniae.

8. Lung phagocyte bactericidal function in strains of mice resistant and susceptible to Pseudomonas aeruginosa.

9. Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia.

10. Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa.