| Literature DB >> 7694032 |
R Spangler1, E M Unterwald, M J Kreek.
Abstract
Other workers have established that cocaine injections increase the levels of dynorphin peptides in the caudate putamen and substantia nigra of the rat brain. Using a quantitative solution hybridization protection assay for mRNA, we detected a significant increase in the concentration of prodynorphin mRNA in caudate putamen extracts of rats injected with cocaine following a 'binge' administration pattern designed to mimic human cocaine abuse. Increased prodynorphin mRNA was observed at the earliest time-point studied (50 h) and the lowest dose (10 mg/kg/day) of cocaine tested and persisted through the 14 day period studied. No prodynorphin mRNA was detected in the substantia nigra.Entities:
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Year: 1993 PMID： 7694032 DOI： 10.1016/0169-328x(93)90133-a
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X