Literature DB >> 7693856

Novel role of interleukin 7 in myelopoiesis: stimulation of primitive murine hematopoietic progenitor cells.

F W Jacobsen1, O P Veiby, C Skjønsberg, S E Jacobsen.   

Abstract

Interleukin 7 (IL-7) has been demonstrated to be an important regulator of the growth of B and T cell precursors as well as mature T cells, whereas IL-7 has been reported to have no direct myeloproliferative effects. Here we show that IL-7 potently and directly enhances colony stimulating factor-induced myeloid colony formation from Lin-Sca-1+ murine bone marrow progenitor cells, increasing the cloning frequency up to ninefold and cell numbers up to 50-fold, without affecting their ability to differentiate along the myeloid lineages In contrast, IL-7 has no effect on proliferation of committed Lin- myeloid progenitors. Thus, in addition to its established lymphopoietic potential, this study implicates a novel role of IL-7 in early myelopoiesis.

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Year:  1993        PMID： 7693856      PMCID： PMC2191229          DOI： 10.1084/jem.178.5.1777

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  28 in total

Review 1.  Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators.

Authors:  M A Moore
Journal:  Blood       Date:  1991-07-01       Impact factor: 22.113

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Authors:  G J Spangrude; L Smith; N Uchida; K Ikuta; S Heimfeld; J Friedman; I L Weissman
Journal:  Blood       Date:  1991-09-15       Impact factor: 22.113

3.  Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver--conditioned medium.

Authors:  K M Zsebo; J Wypych; I K McNiece; H S Lu; K A Smith; S B Karkare; R K Sachdev; V N Yuschenkoff; N C Birkett; L R Williams
Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

4.  The effects of interleukin 7 (IL-7) on human bone marrow in vitro.

Authors:  R J Tushinski; I B McAlister; D E Williams; A E Namen
Journal:  Exp Hematol       Date:  1991-09       Impact factor: 3.084

Review 5.  Colony-forming cells with high proliferative potential (HPP-CFC).

Authors:  I K McNiece; I Bertoncello; A B Kriegler; P J Quesenberry
Journal:  Int J Cell Cloning       Date:  1990-05

6.  The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

Authors:  I K McNiece; K E Langley; K M Zsebo
Journal:  J Immunol       Date:  1991-06-01       Impact factor: 5.422

7.  Effects of rrSCF on multiple cytokine responsive HPP-CFC generated from SCA+Lin- murine hematopoietic progenitors.

Authors:  P A Lowry; K M Zsebo; D H Deacon; C E Eichman; P J Quesenberry
Journal:  Exp Hematol       Date:  1991-10       Impact factor: 3.084

8.  Resting and activated subsets of mouse multipotent hematopoietic stem cells.

Authors:  G J Spangrude; G R Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

9.  Interleukin 7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes.

Authors:  M R Alderson; T W Tough; S F Ziegler; K H Grabstein
Journal:  J Exp Med       Date:  1991-04-01       Impact factor: 14.307

10.  Murine interleukin 7 (IL-7) receptor. Characterization on an IL-7-dependent cell line.

Authors:  L S Park; D J Friend; A E Schmierer; S K Dower; A E Namen
Journal:  J Exp Med       Date:  1990-04-01       Impact factor: 14.307
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  7 in total

1.  Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model.

Authors:  M A Dao; K A Pepper; J A Nolta
Journal:  Stem Cells       Date:  1997       Impact factor: 6.277

2.  Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.

Authors:  T R Kollmann; A Kim; X Zhuang; M Hachamovitch; H Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

3.  Determination of lymphoid cell fate is dependent on the expression status of the IL-7 receptor.

Authors:  Sheetal J Purohit; Robert P Stephan; Hyung-Gyoon Kim; Brantley R Herrin; Larry Gartland; Christopher A Klug
Journal:  EMBO J       Date:  2003-10-15       Impact factor: 11.598

4.  Role of the 75-kDa tumor necrosis factor receptor: inhibition of early hematopoiesis.

Authors:  F W Jacobsen; M Rothe; L Rusten; D V Goeddel; E B Smeland; O P Veiby; L Slørdal; S E Jacobsen
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

5.  The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44.

Authors:  C Márquez; C Trigueros; E Fernández; M L Toribio
Journal:  J Exp Med       Date:  1995-02-01       Impact factor: 14.307

6.  Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7.

Authors:  K J Grzegorzewski; K L Komschlies; S E Jacobsen; F W Ruscetti; J R Keller; R H Wiltrout
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307

7.  Interleukin 13: novel role in direct regulation of proliferation and differentiation of primitive hematopoietic progenitor cells.

Authors:  S E Jacobsen; C Okkenhaug; O P Veiby; D Caput; P Ferrara; A Minty
Journal:  J Exp Med       Date:  1994-07-01       Impact factor: 14.307
  7 in total

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