Line-associated bacteraemias.

Sepsis associated with intravascular catheters is a significant cause of morbidity and mortality in England and Wales. Almost 4000 cases of line-associated bacteraemia were reported to the PHLS Communicable Disease Surveillance Centre in 1991. The clinical and laboratory criteria used to diagnose these infections are reviewed and several approaches to the prevention of catheter-related sepsis are described, including the use of smooth antimicrobial polymers and electrical charge. The strict application of appropriate aseptic techniques is still, however, the most important factor in reducing the incidence of sepsis.