| Literature DB >> 7692575 |
M L Michel1, M Mancini, K Schlienger, P Tiollais.
Abstract
Eukaryotic cells transformed with a plasmid expression vector are able to synthesize and assemble HBsAg, a complex multimeric lipoprotein particle. Hybrid particles carrying HIV1 antigenic determinants were constructed and injected into monkeys. A complete immune response including neutralizing antibodies, proliferative and cytotoxic T-cell activities was obtained. Thus, such HIV/HBsAg hybrid particles could be a new approach to multivalent vaccination.Entities:
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Year: 1993 PMID： 7692575 DOI： 10.1016/s0923-2516(06)80038-5
Source DB: PubMed Journal: Res Virol ISSN： 0923-2516