Chromosomal aberrations in cultured human lymphocytes treated with Marshal and its effective ingredient Carbosulfan.

The aim of this study was to investigate the ability of Marshal (insecticide/nematocide) and its effective ingredient Carbosulfan to induce chromosomal aberrations (CA) and other chromosomal abnormalities in human peripheral lymphocytes. Carbosulfan induced the formation of CA at all concentrations (10(-6), 5 x 10(-6), 10(-5), 5 x 10(-5) v/v) and treatment times. Marshal significantly induced the formation of CA at the two highest concentrations (10(-5) and 5 x 10(-5) v/v) at all treatment times. The extent of damage was greatest with Carbosulfan.