Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane.

365 individuals exposed to hexachlorocyclohexane (HCH) during its manufacture were studied and compared with 146 controls. These 502 cases were divided into five groups on the basis of serum total HCH levels. Exposure was mainly through skin. Results indicate that neurological symptoms reported were due to recent exposure to HCH and were related to the intensity of exposure. ECG abnormalities were seen in exposed cases. A significant positive correlation to liver related enzymes gamma GT, LAP and Alp. P was observed. beta-globulins significantly increased along with an increase in total HCH. Changes in IgM levels were similar as observed in IgA. Remarkably high concentration of HCH residues were found in the serum samples of all exposed workers. beta-HCH contributed more than 80% of the total HCH built up. Presence of circulating immune complexes was also detected in representative samples. Further, repeated biological monitoring was advised to be carried out among such workers exposed to HCH, to evaluate signs of severe health impairment in them.