Literature DB >> 7691729

Non-major histocompatibility complex-restricted killer cells in human cord blood: generation and cytotoxic activity in recombinant interleukin-2-supplemented cultures.

A M Malygin1, T Timonen.   

Abstract

Interleukin-2 (IL-2)-induced generation of non-major histocompatibility complex (MHC)-restricted killer cells among human cord blood lymphocytes (CBL) was investigated. After 1 week in culture with recombinant (r)IL-2 and human serum (HuSer), the cytotoxicity of CBL against K562 and COLO cells greatly exceeded the cytotoxicity of cultured adult peripheral blood lymphocytes. Culturing of CBL with rIL-2 and HuSer led to preferable generation of CD56+ cells. After 1 month in culture, the number and frequency of CD56+ cells had increased by more than 50 and nine times, respectively. The generation of CD56+ cells in CBL cultures may at least partially be explained by their comparatively strong expression of the IL-2 receptor (IL-2R) beta-chain (p75).

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Year:  1993        PMID： 7691729      PMCID： PMC1421970     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

Review 1.  Allorecognition by NK cells: nonself or no self?

Authors:  L Moretta; E Ciccone; A Moretta; P Höglund; C Ohlén; K Kärre
Journal:  Immunol Today       Date:  1992-08

Review 2.  On the nature and function of human uterine granular lymphocytes.

Authors:  A King; Y W Loke
Journal:  Immunol Today       Date:  1991-12

3.  Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts.

Authors:  R Kiessling; P S Hochman; O Haller; G M Shearer; H Wigzell; G Cudkowicz
Journal:  Eur J Immunol       Date:  1977-09       Impact factor: 5.532

4.  Human newborns are deficient in natural killer activity.

Authors:  J Kaplan; T C Shope; R O Bollinger; J Smith
Journal:  J Clin Immunol       Date:  1982-10       Impact factor: 8.317

5.  A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

Authors:  T Abo; C M Balch
Journal:  J Immunol       Date:  1981-09       Impact factor: 5.422

6.  Differential expression of the interleukin 2 receptor beta (p75) chain on human peripheral blood natural killer subsets.

Authors:  K Nishikawa; S Saito; T Morii; Y Kato; N Narita; M Ichijo; Y Ohashi; T Takeshita; K Sugamura
Journal:  Int Immunol       Date:  1990       Impact factor: 4.823

7.  Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.

Authors:  A Nagler; L L Lanier; J H Phillips
Journal:  J Exp Med       Date:  1990-05-01       Impact factor: 14.307

8.  Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens.

Authors:  L L Lanier; C J Benike; J H Phillips; E G Engleman
Journal:  J Immunol       Date:  1985-02       Impact factor: 5.422

9.  Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors.

Authors:  M A Caligiuri; A Zmuidzinas; T J Manley; H Levine; K A Smith; J Ritz
Journal:  J Exp Med       Date:  1990-05-01       Impact factor: 14.307

Review 10.  Biology of natural killer cells.

Authors:  G Trinchieri
Journal:  Adv Immunol       Date:  1989       Impact factor: 3.543
  10 in total
  1 in total

1.  Differential cytokine regulation of natural killer cell-mediated necrotic and apoptotic cytotoxicity.

Authors:  C M Gardiner; D J Reen
Journal:  Immunology       Date:  1998-04       Impact factor: 7.397
  1 in total

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