Literature DB >> 769160

Insulin-dependent diabetes: a disease of autoaggression.

S W Huang, N K Maclaren.   

Abstract

Lymphocytes from patients with insulin-dependent diabetes demonstrated significant cytoadherence and cytotoxicity against human insulinoma cells in vitro as compared to lymphocytes from normals. Complement was not involved in insulinoma cell destruction. The findings suggest that insulin-dependent diabetes may be a disease of autoaggression.

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Year:  1976        PMID： 769160     DOI： 10.1126/science.769160

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

Review 1.  The differentiation of the immune system towards anti-islet autoimmunity. Clinical prospects.

Authors:  C Boitard
Journal:  Diabetologia       Date:  1992-12       Impact factor: 10.122

Review 2.  Virus-induced diabetes mellitus.

Authors:  A L Notkins
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

3.  Immunoregulatory dysfunctions in type I diabetes: natural and antibody-dependent cellular cytotoxic activities.

Authors:  M P Nair; E W Lewis; S A Schwartz
Journal:  J Clin Immunol       Date:  1986-09       Impact factor: 8.317

Review 4.  Juvenile diabetes mellitus: possibility of prevention.

Authors:  J W Farquhar
Journal:  Arch Dis Child       Date:  1979-08       Impact factor: 3.791

Review 5.  Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus.

Authors:  D W Drell; A L Notkins
Journal:  Diabetologia       Date:  1987-03       Impact factor: 10.122

6.  Some aspects of the genetics and etiology of spontaneous diabetes mellitus.

Authors:  E Pimentel
Journal:  Acta Diabetol Lat       Date:  1979 Jul-Sep

7.  Remission from insulin dependence induced by continuous subcutaneous insulin infusion (CSII) in type I, newly diagnosed diabetics: role of some hormonal and immunologic factors.

Authors:  G M Nardelli; E Guastamacchia; S Di Paolo; V Lattanzi; A Ciampolillo; P Montedoro; R Giorgino
Journal:  Acta Diabetol Lat       Date:  1988 Oct-Dec

8.  Immunological aspect of non-obese diabetic mice: immune islet cell-killing mechanism and cell-mediated immunity.

Authors:  T Maruyama; I Takei; M Taniyama; K Kataoka; S Matsuki
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122

9.  Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell line.

Authors:  R C McEvoy; J Andersson; S Sandler; C Hellerström
Journal:  J Clin Invest       Date:  1984-09       Impact factor: 14.808

10.  Alterations in lymphocyte subpopulations in type 1 (insulin-dependent) diabetes mellitus: exploration of possible mechanisms and relationships to autoimmune phenomena.

Authors:  K C Herold; A Huen; L Gould; H Traisman; A H Rubenstein
Journal:  Diabetologia       Date:  1984-07       Impact factor: 10.122
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