Literature DB >> 7691479

Human alpha-satellite DNAs are not susceptible to undercondensation after 5-azacytidine treatment.

J L Fernández1, V Goyanes, C López-Fernández, J Gosálvez.   

Abstract

Localization of alphoid human satellite DNAs using fluorescence in situ hybridization (FISH) of metaphase chromosomes following treatment with 5-azacytidine to produce undercondensation showed that human alpha-satellite DNA is not sensitive to the condensation-inhibition effect of 5-azacytidine. The difference in heterochromatic DNA subsets was particularly evident in the constitutive heterochromatin of chromosomes 1 and 9. Comparison of the results obtained after FISH with those obtained from electron microscopy and G-banding enabled accurate localization of this DNA domain.

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Year:  1994        PMID： 7691479     DOI： 10.1159/000133607

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  4 in total

1.  An extra band within the human 9qh+ region that behaves like the surrounding constitutive heterochromatin.

Authors:  J L Fernández; S Pereira; A Campos; J Gosálvez; V Goyanes
Journal:  J Med Genet       Date:  1994-08       Impact factor: 6.318

2.  5-azacytidine produces differential undercondensation of alpha, beta and classical human satellite DNAs.

Authors:  J L Fernández; V Goyanes; S Pereira; C López-Fernández; J Gosálvez
Journal:  Chromosome Res       Date:  1994-01       Impact factor: 5.239

3.  Rare variants of chromosome 9 with extra G positive band within the qh region are not alike.

Authors:  R A Conte; S Gupta; J P Brennan; R S Verma
Journal:  J Med Genet       Date:  1995-05       Impact factor: 6.318

4.  Differential digestion of the centromeric heterochromatic regions of the 5-azacytidine-decondensed human chromosomes 1, 9, 15, and 16 by NdeII and Sau3AI restriction endonucleases.

Authors:  P Martínez; C Bouza; A Viñas; L Sánchez
Journal:  Genetica       Date:  1995       Impact factor: 1.082
  4 in total

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