Literature DB >> 7691337

Effect of ageing on rat liver regeneration after partial hepatectomy.

I Tsukamoto1, R Nakata, S Kojo.   

Abstract

The effect of ageing on liver regeneration after two-thirds partial hepatectomy was evaluated using rats of 6 and 60 weeks of age. The induction of thymidylate synthase and thymidine kinase, which are rate-determining enzymes of DNA synthesis in liver regeneration, delayed by 24 h and the maximal activities were significantly lower in old rats. Effects of aging on liver weight and synthesis of DNA, RNA and protein were discussed quantitatively in terms of the relative restoration yield deduced from the comparison with the young animals.

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Year:  1993        PMID： 7691337

Source DB:  PubMed          Journal:  Biochem Mol Biol Int        ISSN： 1039-9712


  7 in total

1.  Outcomes among older adult liver transplantation recipients in the model of end stage liver disease (MELD) era.

Authors:  Maricar F Malinis; Shu Chen; Heather G Allore; Vincent J Quagliarello
Journal:  Ann Transplant       Date:  2014-09-26       Impact factor: 1.530

2.  Liver function declines with increased age.

Authors:  Kasia P Cieslak; Onno Baur; Joanne Verheij; Roelof J Bennink; Thomas M van Gulik
Journal:  HPB (Oxford)       Date:  2016-06-20       Impact factor: 3.647

3.  Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver.

Authors:  Pallavi Singh; Triona Goode; Adam Dean; Samir S Awad; Gretchen J Darlington
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2011-06-30       Impact factor: 6.053

4.  Lack of grafted liver rejuvenation in adult-to-pediatric liver transplantation.

Authors:  Susumu Eguchi; Mitsuhisa Takatsuki; Masaaki Hidaka; Akihiko Soyama; Izumi Muraoka; Tetsuo Tomonaga; Isao Shimokawa; Takashi Kanematsu
Journal:  Dig Dis Sci       Date:  2010-10-09       Impact factor: 3.199

5.  Liver failure following partial hepatectomy.

Authors:  Thomas S Helling
Journal:  HPB (Oxford)       Date:  2006       Impact factor: 3.647

6.  Influence of donor liver telomere and G-tail on clinical outcome after living donor liver transplantation.

Authors:  Biou Liu; Kumiko Anno; Tsuyoshi Kobayashi; Jinlian Piao; Hidetoshi Tahara; Hideki Ohdan
Journal:  PLoS One       Date:  2019-03-07       Impact factor: 3.240

Review 7.  Utilization of expanded criteria donors in liver transplantation.

Authors:  Reza F Saidi
Journal:  Int J Organ Transplant Med       Date:  2013
  7 in total

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