Literature DB >> 7690554

Evidence for progesterone receptors in human osteoblast-like cells.

L L Wei1, M W Leach, R S Miner, L M Demers.   

Abstract

We report on the presence of progesterone receptor and its mRNA in a human osteoblast-like cell line (HOS TE85) using recombinant DNA methods, saturation analysis, specific immunoprecipitation with an anti-progesterone receptor antibody, and Northern blot analysis. These osteoblast-like cells were also found to be responsive to progesterone in a dose-dependent fashion through an augmentation in cellular alkaline phosphatase activity. These results support the presence of progesterone receptors in bone cells and suggest a direct effort of progesterone and/or antiprogestins on osteoblast cell function.

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Year:  1993        PMID： 7690554     DOI： 10.1006/bbrc.1993.2077

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Progesterone-mediated stimulation of osteoprogenitor proliferation and differentiation in cell populations derived from adult or fetal rat bone tissue depends on the serum component of the culture media.

Authors:  Y Ishida; C G Bellows; I Tertinegg; J N Heersche
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

2.  Sex dimorphic regulation of osteoprogenitor progesterone in bone stromal cells.

Authors:  Alexander Kot; Zhendong A Zhong; Hongliang Zhang; Yu-An Evan Lay; Nancy E Lane; Wei Yao
Journal:  J Mol Endocrinol       Date:  2017-09-04       Impact factor: 5.098

3.  Age and gender specific stimulation of creatine kinase specific activity by gonadal steroids in human bone-derived cells in culture.

Authors:  S Katzburg; A Ornoy; D Hendel; M Lieberherr; A M Kaye; D Somjen
Journal:  J Endocrinol Invest       Date:  2001-03       Impact factor: 4.256

4.  Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles.

Authors:  B Niethammer; C Körner; M Schmidmayr; P B Luppa; V R Seifert-Klauss
Journal:  Geburtshilfe Frauenheilkd       Date:  2015-12       Impact factor: 2.915

5.  Sex-Dependent, Osteoblast Stage-Specific Effects of Progesterone Receptor on Bone Acquisition.

Authors:  Zhendong A Zhong; Alexander Kot; Yu-An E Lay; Hongliang Zhang; Junjing Jia; Nancy E Lane; Wei Yao
Journal:  J Bone Miner Res       Date:  2017-07-13       Impact factor: 6.741

6.  Inhibition of the progesterone nuclear receptor during the bone linear growth phase increases peak bone mass in female mice.

Authors:  Wei Yao; Weiwei Dai; Mohammad Shahnazari; Aaron Pham; Zhiqiang Chen; Haiyan Chen; Min Guan; Nancy E Lane
Journal:  PLoS One       Date:  2010-07-01       Impact factor: 3.240

7.  Bone growth and turnover in progesterone receptor knockout mice.

Authors:  David J Rickard; Urszula T Iwaniec; Glenda Evans; Theresa E Hefferan; Jamie C Hunter; Katrina M Waters; John P Lydon; Bert W O'Malley; Sundeep Khosla; Thomas C Spelsberg; Russell T Turner
Journal:  Endocrinology       Date:  2008-02-14       Impact factor: 4.736

8.  Progesterone receptors are expressed in human osteoblast-like cell lines and in primary human osteoblast cultures.

Authors:  P MacNamara; C O'Shaughnessy; P Manduca; H C Loughrey
Journal:  Calcif Tissue Int       Date:  1995-12       Impact factor: 4.333

9.  Inactivation of the Progesterone Receptor in Mx1+ Cells Potentiates Osteogenesis in Calvaria but Not in Long Bone.

Authors:  Zhendong A Zhong; Weihua Sun; Haiyan Chen; Hongliang Zhang; Nancy E Lane; Wei Yao
Journal:  PLoS One       Date:  2015-10-02       Impact factor: 3.240

10.  Selective inhibition of progesterone receptor in osteochondral progenitor cells, but not in mature chondrocytes, modulated subchondral bone structures.

Authors:  Chenlin Dai; Junjing Jia; Alexander Kot; Xueping Liu; Lixian Liu; Min Jiang; Nancy E Lane; Barton L Wise; Wei Yao
Journal:  Bone       Date:  2019-12-19       Impact factor: 4.398
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