Literature DB >> 7690553

Nitric oxide production by murine macrophages is inhibited by prolonged elevation of cyclic AMP.

V Bulut1, A Severn, F Y Liew.   

Abstract

Murine macrophages produce large amounts of nitric oxide (NO) on stimulation by interferon (IFN)-gamma and lipopolysaccharide (LPS) or a high concentration of LPS alone. Agents which increase intracellular cAMP levels inhibit cytokine production by macrophages. The effect of increased intracellular cAMP levels on NO production was investigated, using a murine macrophage cell line, J774. NO production was reduced by prolonged elevation of cAMP, but not by a transient increase.

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Year:  1993        PMID： 7690553     DOI： 10.1006/bbrc.1993.2162

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Isoproterenol regulates tumour necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxaemia.

Authors:  C Szabó; G Haskó; B Zingarelli; Z H Németh; A L Salzman; V Kvetan; S M Pastores; E S Vizi
Journal:  Immunology       Date:  1997-01       Impact factor: 7.397

Review 2.  The role of cAMP regulation in controlling inflammation.

Authors:  A R Moore; D A Willoughby
Journal:  Clin Exp Immunol       Date:  1995-09       Impact factor: 4.330

3.  Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit.

Authors:  J L Bellot; M Palmero; C García-Cabanes; R Espí; C Hariton; A Orts
Journal:  Inflamm Res       Date:  1996-04       Impact factor: 4.575

4.  Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and interleukin-10.

Authors:  R B Zinyama; G J Bancroft; L B Sigola
Journal:  Immunology       Date:  2001-12       Impact factor: 7.397

5.  Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone.

Authors:  R A Star; N Rajora; J Huang; R C Stock; A Catania; J M Lipton
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205

6.  In vitro effects of cAMP-elevating agents and glucocorticoid either alone or in combination on the production of nitric oxide, interleukin-12 and interleukin-10 in IFN-gamma- and LPS-activated mouse peritoneal macrophages.

Authors:  J Mittal; N Dogra; R Dass; S Majumdar
Journal:  Folia Microbiol (Praha)       Date:  2002       Impact factor: 2.099

7.  Increased intracellular Ca2+ selectively suppresses IL-1-induced NO production by reducing iNOS mRNA stability.

Authors:  Y Geng; M Lotz
Journal:  J Cell Biol       Date:  1995-06       Impact factor: 10.539

8.  Modulation of nitric oxide synthase activity in macrophages.

Authors:  P G Jorens; K E Matthys; H Bult
Journal:  Mediators Inflamm       Date:  1995       Impact factor: 4.711

9.  Nitric oxide production in murine spleen cells: role of interferons and prostaglandin E(2) in the generation of cytotoxic activity.

Authors:  D Vaillier; R Daculsi; N Gualdel
Journal:  Mediators Inflamm       Date:  1996       Impact factor: 4.711
  9 in total

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