Literature DB >> 7690497

Immunoglobulin VH3 gene products: natural ligands for HIV gp120.

L Berberian1, L Goodglick, T J Kipps, J Braun.   

Abstract

Infection with human immunodeficiency virus-type 1 (HIV-1) depletes T cells expressing CD4 and B cells expressing immunoglobulin (Ig) VH3 gene products. A subpopulation of normal B cells from non-HIV-infected individuals was shown to bind to HIV gp120 by means of membrane Ig; most of these B cells expressed VH3 family Ig. Serum VH3 IgM from uninfected individuals also avidly bound gp120. Finally, gp120 selectively induced Ig secretion by VH3 B cells, indicating that the binding of gp120 functionally activated these cells. These results indicate that naturally occurring VH3 Ig is a second ligand for gp120 and a candidate superantigen for VH3 B cells.

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Year:  1993        PMID： 7690497     DOI： 10.1126/science.7690497

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  77 in total

1.  Additive effect of neutralizing antibody and antiviral drug treatment in preventing virus escape and persistence.

Authors:  P Seiler; B M Senn; P Klenerman; U Kalinke; H Hengartner; R M Zinkernagel
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

2.  B lymphocytes in lymph nodes and peripheral blood are important for binding immune complexes containing HIV-1.

Authors:  J J Jakubik; M Saifuddin; D M Takefman; G T Spear
Journal:  Immunology       Date:  1999-04       Impact factor: 7.397

Review 3.  Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires.

Authors:  Michael Zemlin; Robert L Schelonka; Karl Bauer; Harry W Schroeder
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

4.  Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L.

Authors:  Muriel Viau; Nancy S Longo; Peter E Lipsky; Lars Björck; Moncef Zouali
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

5.  Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.

Authors:  M Montesinos-Rongen; R Küppers; D Schlüter; T Spieker; D Van Roost; C Schaller; G Reifenberger; O D Wiestler; M Deckert-Schlüter
Journal:  Am J Pathol       Date:  1999-12       Impact factor: 4.307

6.  Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses.

Authors:  D H Margolin; K A Reimann; J Sodroski; G B Karlsson; K Tenner-Racz; P Racz; N L Letvin
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

Review 7.  Antibodies as defensive enzymes.

Authors:  Sudhir Paul; Yasuhiro Nishiyama; Stephanie Planque; Sangeeta Karle; Hiroaki Taguchi; Carl Hanson; Marc E Weksler
Journal:  Springer Semin Immunopathol       Date:  2005-01-05

8.  Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1.

Authors:  Miroslaw K Gorny; Xiao-Hong Wang; Constance Williams; Barbara Volsky; Kathy Revesz; Bradley Witover; Sherri Burda; Mateusz Urbanski; Phillipe Nyambi; Chavdar Krachmarov; Abraham Pinter; Susan Zolla-Pazner; Arthur Nadas
Journal:  Mol Immunol       Date:  2008-10-25       Impact factor: 4.407

Review 9.  The molecular structure of human antibodies specific for the human immunodeficiency virus.

Authors:  J S Andris; J D Capra
Journal:  J Clin Immunol       Date:  1995-01       Impact factor: 8.317

10.  Sequence analysis of immunoglobulin heavy-chain variable region genes from the synovium of a rheumatoid arthritis patient shows little evidence of mutation but diverse CDR3.

Authors:  C M Brown; K J Fitzgerald; S P Moyes; R A Mageed; D G Williams; R N Maini
Journal:  Immunology       Date:  1995-03       Impact factor: 7.397
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