Literature DB >> 7690233

Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions.

T Ohmori1, T Koyama, A Muraki, I Yamashita.   

Abstract

Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40-60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.

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Year:  1993        PMID： 7690233     DOI： 10.1007/bf01244869

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  23 in total

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Journal:  Neuroscience       Date:  1983-08       Impact factor: 3.590

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Journal:  Neuropharmacology       Date:  1992-04       Impact factor: 5.250

6.  Inhibition by phencyclidine of excitatory amino acid-stimulated release of neurotransmitter in the nucleus accumbens.

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Journal:  Neuropharmacology       Date:  1987 Feb-Mar       Impact factor: 5.250

7.  Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain.

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Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

8.  Glutamatergic control of dopamine release in the rat striatum: evidence for presynaptic N-methyl-D-aspartate receptors on dopaminergic nerve terminals.

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Authors:  A J Hotchkiss; J W Gibb
Journal:  J Pharmacol Exp Ther       Date:  1980-08       Impact factor: 4.030

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Authors:  L D Snell; K M Johnson
Journal:  J Pharmacol Exp Ther       Date:  1986-09       Impact factor: 4.030
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5.  Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures.

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6.  Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine.

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  6 in total

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