Literature DB >> 7689086

Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions.

T Saito1, T Taga, D Miki, K Futatsugi, H Yawata, T Kishimoto, K Yasukawa.   

Abstract

mAbs specific to human gp130, a signal transducing component of the IL-6 receptor complex, were prepared by immunizing mice with a previously described recombinant human soluble gp130. Some of the mAbs inhibited the IL-6-induced association of soluble gp130 and soluble IL-6 receptor. Three mAbs (GPX7, GPX22 and GPZ35) were shown to inhibit IL-6-mediated biological responses such as Ig production in a human B cell line and proliferative responses of a human Lennert's lymphoma-derived T cell line, a human myeloma cell line, and a mouse pro-B cell line-derived transfectant expressing human gp130.

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Year:  1993        PMID： 7689086     DOI： 10.1016/0022-1759(93)90125-q

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  8 in total

Review 1.  Interleukin-6: structure-function relationships.

Authors:  R J Simpson; A Hammacher; D K Smith; J M Matthews; L D Ward
Journal:  Protein Sci       Date:  1997-05       Impact factor: 6.725

2.  Identification of a novel antigenic structure of the human receptor for interleukin-6 involved in the interaction with the glycoprotein 130 chain.

Authors:  J P Gaillard; J Liautard; J C Mani; J M Fernandez Suarez; B Klein; J Brochier
Journal:  Immunology       Date:  1996-09       Impact factor: 7.397

3.  gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells.

Authors:  X Sui; K Tsuji; R Tanaka; S Tajima; K Muraoka; Y Ebihara; K Ikebuchi; K Yasukawa; T Taga; T Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

4.  Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells.

Authors:  S Tajima; K Tsuji; Y Ebihara; X Sui; R Tanaka; K Muraoka; M Yoshida; K Yamada; K Yasukawa; T Taga; T Kishimoto; T Nakahata
Journal:  J Exp Med       Date:  1996-10-01       Impact factor: 14.307

5.  Preferential proliferation of murine colony-forming units in culture in a chemically defined condition with a macrophage colony-stimulating factor-negative stromal cell clone.

Authors:  N Takakura; H Kodama; S Nishikawa; S Nishikawa
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307

6.  Erythropoietin-independent erythrocyte production: signals through gp130 and c-kit dramatically promote erythropoiesis from human CD34+ cells.

Authors:  X Sui; K Tsuji; S Tajima; R Tanaka; K Muraoka; Y Ebihara; K Ikebuchi; K Yasukawa; T Taga; T Kishimoto; T Nakahata
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307

7.  Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

Authors:  X G Zhang; J J Gu; Z Y Lu; K Yasukawa; G D Yancopoulos; K Turner; M Shoyab; T Taga; T Kishimoto; R Bataille
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307

8.  Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

Authors:  N Nishimoto; A Ogata; Y Shima; Y Tani; H Ogawa; M Nakagawa; H Sugiyama; K Yoshizaki; T Kishimoto
Journal:  J Exp Med       Date:  1994-04-01       Impact factor: 14.307
  8 in total

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