Literature DB >> 7689063

Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.

G F Sud'ina1, O K Mirzoeva, M A Pushkareva, G A Korshunova, N V Sumbatyan, S D Varfolomeev.   

Abstract

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 microM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

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Year:  1993        PMID： 7689063     DOI： 10.1016/0014-5793(93)80184-v

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  83 in total

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Authors:  N L Nadon; R Strong; R A Miller; J Nelson; M Javors; Z D Sharp; J M Peralba; D E Harrison
Journal:  Age (Dordr)       Date:  2008-04-18

2.  Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats.

Authors:  S Oktar; Z Yönden; M Aydin; S Ilhan; E Alçin; O H Oztürk
Journal:  J Physiol Biochem       Date:  2009-12       Impact factor: 4.158

3.  Inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin.

Authors:  G Began; E Sudharshan; A G Appu Rao
Journal:  Lipids       Date:  1998-12       Impact factor: 1.880

4.  Ameliorating effects of CAPE on oxidative damage caused by pneumoperitoneum in rat lung tissue.

Authors:  Isil Davarci; Harun Alp; Tumay Ozgur; Murat Karcioglu; Kasim Tuzcu; Osman Evliyaoglu; Sedat Motor; Tulin Durgun Yetim
Journal:  Int J Clin Exp Med       Date:  2014-07-15

5.  Effect of caffeic acid phenethyl ester on myringosclerosis development in the tympanic membrane of rat.

Authors:  Vefa Kinis; Musa Ozbay; Ulas Alabalik; Aylin Gul; Beyhan Yilmaz; Fazi Emre Ozkurt; Engin Sengul; Ismail Topcu
Journal:  Eur Arch Otorhinolaryngol       Date:  2013-11-27       Impact factor: 2.503

6.  Icariin, Formononetin and Caffeic Acid Phenethyl Ester Inhibit Feline Calicivirus Replication In Vitro.

Authors:  Zhanding Cui; Qian Wang; Dengliang Li; Shihui Zhao; Qian Zhang; Yuxin Tan; Qianwen Gong; Ting Liu; Jiang Shao; Shuang Zhang; Hailong Huang; Junzheng Wang; Zhihua Pei; Hao Dong; Kai Wang; Guixue Hu; Zhiyong Li
Journal:  Arch Virol       Date:  2021-06-25       Impact factor: 2.574

7.  The Effect of Caffeic Acid on Wound Healing in Skin-incised Mice.

Authors:  Ho Sun Song; Tae Wook Park; Uy Dong Sohn; Yong Kyoo Shin; Byung Chul Choi; Chang Jong Kim; Sang Soo Sim
Journal:  Korean J Physiol Pharmacol       Date:  2008-12-31       Impact factor: 2.016

8.  The effects of caffeic acid phenethyl ester (CAPE) on TNBS-induced colitis in ovariectomized rats.

Authors:  Rauf Onur Ek; Mukadder Serter; Kemal Ergin; Yuksel Yildiz; Serpil Cecen; Tulay Kavak; Cigdem Yenisey
Journal:  Dig Dis Sci       Date:  2008-06       Impact factor: 3.199

9.  Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes.

Authors:  Jaspreet Singh; Mushfiquddin Khan; Inderjit Singh
Journal:  Biochim Biophys Acta       Date:  2013-01-11

10.  An in vitro screening cascade to identify neuroprotective antioxidants in ALS.

Authors:  Siân C Barber; Adrian Higginbottom; Richard J Mead; Stuart Barber; Pamela J Shaw
Journal:  Free Radic Biol Med       Date:  2009-01-30       Impact factor: 7.376
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