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Literature DB >> 7688275

Role of somatostatin in regulation of insular-acinar axis.

M K Müller¹, J von Schönfeld, M V Singer.

Abstract

Cysteamine is known to deplete somatostatin from pancreatic D cells. In the isolated perfused rat pancreas we investigated its effects on somatostatin and glucagon release as well as exocrine pancreatic secretion in the presence of 1.8 mM glucose. Cysteamine, 10 mM, released somatostatin, but had no effect on CCK-stimulated amylase secretion. Arginine-stimulated glucagon release, however, was significantly inhibited by cysteamine. Concomitantly we still observed stimulation of somatostatin secretion, but also a potentiation of CCK-stimulated amylase secretion. Our results are consistent with a role of somatostatin in the regulation of exocrine pancreatic secretion via its effect on pancreatic A and B cells.

Entities: Chemical Disease Gene Species

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Year: 1993 PMID： 7688275 DOI： 10.1007/bf01308617

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

33 in total

1. Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine.

Authors: M K Müller; K Bergmann; H Degenhardt; G Klöppel; M Löhr; H J Coone; H Goebell
Journal: Transplantation Date: 1988-04 Impact factor: 4.939

2. Why are the islets of Langerhans?

Authors: J R Henderson
Journal: Lancet Date: 1969-08-30 Impact factor: 79.321

3. Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function.

Authors: M Itoh; L Mandarino; J E Gerich
Journal: Diabetes Date: 1980-09 Impact factor: 9.461

4. Cysteamine induces cholecystokinin release from the duodenum. Evidence for somatostatin as an inhibitory paracrine regulator of cholecystokinin secretion in the rat.

Authors: J Abucham; S Reichlin
Journal: Gastroenterology Date: 1990-12 Impact factor: 22.682

5. Rapid depletion of somatostatin in isolated mouse pancreatic islets after treatment with cysteamine.

Authors: B Petersson; C Hellerström
Journal: Acta Endocrinol (Copenh) Date: 1985-10

6. Interrelationships between alpha and beta-anomers of glucose affecting both insulin and glucagon secretion in the perfused rat pancreas. II.

Authors: G M Grodsky; R Fanska; I Lundquist
Journal: Endocrinology Date: 1975-09 Impact factor: 4.736

7. The effect of the duodenal ulcerogen cysteamine on somatostatin and gastrin cells in the rat.

Authors: M Seiler; S Szabo; S Ourieff; D J McComb; K Kovacs; S Reichlin
Journal: Exp Mol Pathol Date: 1983-10 Impact factor: 3.362

8. Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion.

Authors: Y C Patel; I Pierzchala; M Amherdt; L Orci
Journal: J Clin Invest Date: 1985-04 Impact factor: 14.808

Role of somatostatin in regulation of insular-acinar axis.

1. Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine.

2. Why are the islets of Langerhans?

3. Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function.

4. Cysteamine induces cholecystokinin release from the duodenum. Evidence for somatostatin as an inhibitory paracrine regulator of cholecystokinin secretion in the rat.

5. Rapid depletion of somatostatin in isolated mouse pancreatic islets after treatment with cysteamine.

6. Interrelationships between alpha and beta-anomers of glucose affecting both insulin and glucagon secretion in the perfused rat pancreas. II.

7. The effect of the duodenal ulcerogen cysteamine on somatostatin and gastrin cells in the rat.

8. Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion.

9. Is somatostatin a true local inhibitory regulator of insulin secretion?

10. Cysteamine and the endocrine pancreas: immunocytochemical, immunochemical, and functional aspects.

Review 1. The islet-acinar axis of the pancreas.

2. Effects of somatostatin (SMS) on pancreatic microcirculation.

3. The islet-acinar axis of the pancreas: is there a role for glucagon or a glucagon-like peptide?