Literature DB >> 7687428

CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.

C M Roifman1, S Ke.   

Abstract

The B cell antigen receptor, mIg, is part of a multimolecular complex including Ig alpha, Ig beta, and CD19. We provide evidence here that upon ligation of mIg CD19 becomes phosphorylated on tyrosine residues. Further, protein tyrosine kinase lyn, which is activated by the antigen receptor, can be readily co-immunoprecipitated with CD19 suggesting this is the enzyme responsible for the antigen receptor mediated tyrosine phosphorylation of CD19.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7687428     DOI： 10.1006/bbrc.1993.1807

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

Review 1.  Combination of celecoxib (Celebrex®) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas.

Authors:  Tam Nm Dinh; Alexandra S Onea; Ali R Jazirehi
Journal:  Am J Clin Exp Immunol       Date:  2017-05-15

2.  Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production.

Authors:  Michelle K Gleason; Michael R Verneris; Deborah A Todhunter; Bin Zhang; Valarie McCullar; Sophia X Zhou; Angela Panoskaltsis-Mortari; Louis M Weiner; Daniel A Vallera; Jeffrey S Miller
Journal:  Mol Cancer Ther       Date:  2012-10-17       Impact factor: 6.261

3.  Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn.

Authors:  Mark Rovedo; Richard Longnecker
Journal:  J Virol       Date:  2008-06-25       Impact factor: 5.103

4.  Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.

Authors:  A M Buhl; C M Pleiman; R C Rickert; J C Cambier
Journal:  J Exp Med       Date:  1997-12-01       Impact factor: 14.307

5.  Differential Requirement of Vav Proteins for Btk-dependent and -Independent Signaling During B Cell Development.

Authors:  Annika C Betzler; Sebastian Kieser; Katja Fiedler; Simon Laban; Marie-Nicole Theodoraki; Patrick J Schuler; Thomas Wirth; Kerry Tedford; Klaus-Dieter Fischer; Thomas K Hoffmann; Cornelia Brunner
Journal:  Front Cell Dev Biol       Date:  2022-02-23

Review 6.  Resistance Mutations to BTK Inhibitors Originate From the NF-κB but Not From the PI3K-RAS-MAPK Arm of the B Cell Receptor Signaling Pathway.

Authors:  C I Edvard Smith; Jan A Burger
Journal:  Front Immunol       Date:  2021-06-10       Impact factor: 7.561
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.