Literature DB >> 7687074

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels.

A Butler1, S Tsunoda, D P McCobb, A Wei, L Salkoff.   

Abstract

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

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Year:  1993        PMID： 7687074     DOI： 10.1126/science.7687074

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  266 in total

1.  Extracellular links in Kir subunits control the unitary conductance of SUR/Kir6.0 ion channels.

Authors:  V P Repunte; H Nakamura; A Fujita; Y Horio; I Findlay; L Pott; Y Kurachi
Journal:  EMBO J       Date:  1999-06-15       Impact factor: 11.598

2.  Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.

Authors:  X M Xia; J P Ding; C J Lingle
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

3.  A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Authors:  T M Weiger; M H Holmqvist; I B Levitan; F T Clark; S Sprague; W J Huang; P Ge; C Wang; D Lawson; M E Jurman; M A Glucksmann; I Silos-Santiago; P S DiStefano; R Curtis
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

4.  beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells.

Authors:  K Ramanathan; T H Michael; P A Fuchs
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

5.  The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea.

Authors:  E M Jones; M Gray-Keller; R Fettiplace
Journal:  J Physiol       Date:  1999-08-01       Impact factor: 5.182

6.  ATP inhibition of a mouse brain large-conductance K+ (mslo) channel variant by a mechanism independent of protein phosphorylation.

Authors:  A G Clark; S K Hall; M J Shipston
Journal:  J Physiol       Date:  1999-04-01       Impact factor: 5.182

7.  Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels.

Authors:  Ying-Wei Wang; Jiu Ping Ding; Xiao-Ming Xia; Christopher J Lingle
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

8.  Steady-state and closed-state inactivation properties of inactivating BK channels.

Authors:  Jiu Ping Ding; Christopher J Lingle
Journal:  Biophys J       Date:  2002-05       Impact factor: 4.033

9.  Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel.

Authors:  B L Moss; S D Silberberg; C M Nimigean; K L Magleby
Journal:  Biophys J       Date:  1999-06       Impact factor: 4.033

10.  Stimulatory action of internal protons on Slo1 BK channels.

Authors:  Vladimir Avdonin; Xiang Dong Tang; Toshinori Hoshi
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033
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