| Literature DB >> 7686600 |
E Göker1, J T Lin, T Trippett, Y Elisseyeff, W P Tong, D Niedzwiecki, C Tan, P Steinherz, B I Schweitzer, J R Bertino.
Abstract
We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients might be a contributing cause to the known difference in clinical outcome, since MTX is a key drug in chemotherapy regimens. Adult B-lineage cell ALL blasts and blasts from the patients with T-lineage cell ALL accumulated lower amounts of total MTX and polyglutamates, especially long-chain MTX polyglutamates (glu3-6) than pediatric B-lineage cell ALL blasts. In view of the importance of polyglutamylation of MTX as a determinant of cytotoxicity of this drug, decreased formation of MTX polyglutamates is likely a contributing cause to the lower cure rate in adult ALL and T-lineage cell ALL as compared to childhood B-lineage cell ALL.Entities:
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Year: 1993 PMID： 7686600
Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528