Literature DB >> 7686381

ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites.

I Bezprozvanny1, B E Ehrlich.   

Abstract

The inositol 1,4,5-trisphosphate (IP3) receptor, a Ca(2+)-permeable channel, plays a key role in intracellular Ca2+ signaling. The effects of ATP on the IP3 receptor at the single-channel level were characterized after channel incorporation into planar lipid bilayers. ATP alone was not sufficient to open the IP3-gated channel, but addition of ATP or nonhydrolyzable ATP analogs in the presence of IP3 increased the frequency of channel openings 4.8-fold and increased the average duration of channel openings 2.5-fold; channel conductance was unchanged. High concentrations of ATP (> 4 mM) decreased channel activity most probably by competing with IP3-binding site. Allosteric modulation of IP3-induced Ca2+ release by ATP may contribute to the maintenance of cell viability during periods of energy starvation.

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Year:  1993        PMID： 7686381     DOI： 10.1016/0896-6273(93)90065-y

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  60 in total

1.  Regulation of the type III InsP(3) receptor by InsP(3) and ATP.

Authors:  R E Hagar; B E Ehrlich
Journal:  Biophys J       Date:  2000-07       Impact factor: 4.033

2.  Modulation of type-1 Ins(1,4,5)P3 receptor channels by the FK506-binding protein, FKBP12.

Authors:  Sheila L Dargan; Edward J A Lea; Alan P Dawson
Journal:  Biochem J       Date:  2002-01-15       Impact factor: 3.857

3.  Effect of adenine nucleotides on myo-inositol-1,4,5-trisphosphate-induced calcium release.

Authors:  L Missiaen; J B Parys; H D Smedt; I Sienaert; H Sipma; S Vanlingen; K Maes; R Casteels
Journal:  Biochem J       Date:  1997-08-01       Impact factor: 3.857

4.  ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.

Authors:  D O Mak; S McBride; J K Foskett
Journal:  J Gen Physiol       Date:  2001-04       Impact factor: 4.086

5.  Functional and biochemical analysis of the type 1 inositol (1,4,5)-trisphosphate receptor calcium sensor.

Authors:  Huiping Tu; Elena Nosyreva; Tomoya Miyakawa; Zhengnan Wang; Akiko Mizushima; Masamitsu Iino; Ilya Bezprozvanny
Journal:  Biophys J       Date:  2003-07       Impact factor: 4.033

6.  Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females.

Authors:  Naoto Fujii; Lyra Halili; Maya Sarah Singh; Robert D Meade; Glen P Kenny
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-08-19       Impact factor: 3.619

7.  Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms.

Authors:  Huiping Tu; Zhengnan Wang; Elena Nosyreva; Humbert De Smedt; Ilya Bezprozvanny
Journal:  Biophys J       Date:  2004-11-08       Impact factor: 4.033

Review 8.  The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.

Authors:  Tamara Vervloessem; David I Yule; Geert Bultynck; Jan B Parys
Journal:  Biochim Biophys Acta       Date:  2014-12-10

9.  Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum.

Authors:  I Bezprozvanny; S Bezprozvannaya; B E Ehrlich
Journal:  Mol Biol Cell       Date:  1994-01       Impact factor: 4.138

10.  Modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by protein kinase a and protein phosphatase 1alpha.

Authors:  Tie-Shan Tang; Huiping Tu; Zhengnan Wang; Ilya Bezprozvanny
Journal:  J Neurosci       Date:  2003-01-15       Impact factor: 6.167
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