Literature DB >> 7685688

Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels.

S Hehl1, B Neumcke.   

Abstract

Blockage of ATP-sensitive K+ channels by various drugs has been reported to exhibit a weak concentration dependence with Hill coefficients below unity. This phenomenon is interpreted by a negative cooperativity between K+ channels whereby drug binding to one channel lowers the drug affinities of neighbouring channels. Results are presented for a dimeric and a tetrameric channel model and compared with published experimental data.

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Year:  1993        PMID： 7685688     DOI： 10.1007/bf00205806

Source DB:  PubMed          Journal:  Eur Biophys J        ISSN： 0175-7571            Impact factor:   1.733


  17 in total

1.  Cooperative gating of chloride channel subunits in endothelial cells.

Authors:  A Queyroy; J Verdetti
Journal:  Biochim Biophys Acta       Date:  1992-07-27

2.  Evidence for cooperative interactions in potassium channel gating.

Authors:  J Tytgat; P Hess
Journal:  Nature       Date:  1992-10-01       Impact factor: 49.962

3.  The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.

Authors:  M Kakei; R P Kelly; S J Ashcroft; F M Ashcroft
Journal:  FEBS Lett       Date:  1986-11-10       Impact factor: 4.124

4.  Intracellular ADP activates K+ channels that are inhibited by ATP in an insulin-secreting cell line.

Authors:  M J Dunne; O H Petersen
Journal:  FEBS Lett       Date:  1986-11-10       Impact factor: 4.124

5.  Cytosolic ADP enhances the sensitivity to tolbutamide of ATP-dependent K+ channels from pancreatic B-cells.

Authors:  B J Zünkler; S Lins; T Ohno-Shosaku; G Trube; U Panten
Journal:  FEBS Lett       Date:  1988-11-07       Impact factor: 4.124

6.  Alteration of the conductance of Na+ channels in the nodal membrane of frog nerve by holding potential and tetrodotoxin.

Authors:  B Neumcke; R Stämpfli
Journal:  Biochim Biophys Acta       Date:  1983-01-05

7.  Cytosolic nucleotides enhance the tolbutamide sensitivity of the ATP-dependent K+ channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors.

Authors:  C Schwanstecher; C Dickel; U Panten
Journal:  Mol Pharmacol       Date:  1992-03       Impact factor: 4.436

8.  Different channel properties of Torpedo acetylcholine receptor monomers and dimers reconstituted in planar membranes.

Authors:  H Schindler; F Spillecke; E Neumann
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205

9.  On the mechanism of nucleotide diphosphate activation of the ATP-sensitive K+ channel in ventricular cell of guinea-pig.

Authors:  R T Tung; Y Kurachi
Journal:  J Physiol       Date:  1991-06       Impact factor: 5.182

10.  Influence of membrane thickness and ion concentration on the properties of the gramicidin a channel. Autocorrelation, spectral power density, relaxation and single-channel studies.

Authors:  H A Kolb; E Bamberg
Journal:  Biochim Biophys Acta       Date:  1977-01-04
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  4 in total

1.  Unraveling subunit cooperativity in homotetrameric HCN2 channels.

Authors:  Klaus Benndorf; Susanne Thon; Eckhard Schulz
Journal:  Biophys J       Date:  2012-11-07       Impact factor: 4.033

2.  The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications.

Authors:  C Hilmas; E F Pereira; M Alkondon; A Rassoulpour; R Schwarcz; E X Albuquerque
Journal:  J Neurosci       Date:  2001-10-01       Impact factor: 6.167

3.  KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP.

Authors:  S Hehl; B Neumcke
Journal:  Eur Biophys J       Date:  1994       Impact factor: 1.733

4.  ATP-sensitive potassium channels exhibit variance in the number of open channels below the limit predicted for identical and independent gating.

Authors:  Kee-Hyun Choi; Stuart Licht
Journal:  PLoS One       Date:  2012-05-30       Impact factor: 3.240
  4 in total

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