| Literature DB >> 7685167 |
T D Ocain1, D Longhi, R J Steffan, R G Caccese, S N Sehgal.
Abstract
A triene-modified analog of the potent immunosuppressive agent rapamycin was found to be a potent inhibitor of the peptidyl prolyl cis-trans isomerase activity of human FKBP (Ki = 12.5 nM). This analog was not immunosuppressive in a thymocyte proliferation assay itself, but was able to antagonize the effect of rapamycin. This new analog should be useful as a mechanistic probe for macrocyclic immunosuppressants.Entities:
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Year: 1993 PMID： 7685167 DOI： 10.1006/bbrc.1993.1563
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575