| Literature DB >> 7685074 |
M Shimojo1, Y Imai, K Nakajima, S Mizushima, A Uemura, S Kohsaka.
Abstract
We determined the neurotrophic activity of interleukin-2 (IL-2) on primary cultured neocortical neurons from embryonic rat brain. IL-2 clearly enhanced the viability of cultured neurons in a dose-dependent manner. The neurotrophic effect of IL-2 was completely neutralized by IL-2 antibody. Furthermore, expression of IL-2 receptor mRNA was more pronounced in neurons than in other cultured cells such as astroglia and microglia. These results strongly suggest that IL-2 plays certain roles in the central nervous system as a neurotrophic factor.Entities:
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Year: 1993 PMID： 7685074 DOI： 10.1016/0304-3940(93)90013-b
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046