Literature DB >> 7684471

Fewer protective cytotoxic T-cell epitopes than T-helper-cell epitopes on vesicular stomatitis virus.

T M Kündig1, I Castelmur, M F Bachmann, D Abraham, D Binder, H Hengartner, R M Zinkernagel.   

Abstract

Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.

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Year:  1993        PMID： 7684471      PMCID： PMC237725     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Vesicular stomatitis virus glycoprotein is necessary for H-2-restricted lysis of infected cells by cytotoxic T lymphocytes.

Authors:  A H Hale; O N Witte; D Baltimore; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

2.  The role of vesicular stomatitis virus major glycoprotein in determining the specificity of virus-specific and H-2-restricted cytolytic T cells.

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Journal:  Eur J Immunol       Date:  1980-04       Impact factor: 5.532

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Journal:  J Immunol       Date:  1978-08       Impact factor: 5.422

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Journal:  Nature       Date:  1984 Dec 6-12       Impact factor: 49.962

5.  Cross-reactive cytotoxic T cells to serologically distinct vesicular stomatitis virus.

Authors:  K L Rosenthal; R M Zinkernagel
Journal:  J Immunol       Date:  1980-05       Impact factor: 5.422

Review 6.  T cell response to viral and bacterial infection.

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Journal:  Transplant Rev       Date:  1974

7.  Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle.

Authors:  M Mackett; T Yilma; J K Rose; B Moss
Journal:  Science       Date:  1985-01-25       Impact factor: 47.728

8.  Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus.

Authors:  S Charan; R M Zinkernagel
Journal:  J Immunol       Date:  1986-04-15       Impact factor: 5.422

9.  Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL.

Authors:  D Binder; T M Kündig
Journal:  J Immunol       Date:  1991-06-15       Impact factor: 5.422

10.  Inability of mice to generate cytotoxic T lymphocytes to vesicular stomatitis virus restricted to H-2Kk or H-2Dk.

Authors:  K L Rosenthal; R M Zinkernagel
Journal:  J Immunol       Date:  1981-02       Impact factor: 5.422
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  13 in total

1.  Moving the glycoprotein gene of vesicular stomatitis virus to promoter-proximal positions accelerates and enhances the protective immune response.

Authors:  E B Flanagan; L A Ball; G W Wertz
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses.

Authors:  Michael Garbutt; Ryan Liebscher; Victoria Wahl-Jensen; Steven Jones; Peggy Möller; Ralf Wagner; Viktor Volchkov; Hans-Dieter Klenk; Heinz Feldmann; Ute Ströher
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

3.  Antigen kinetics determines immune reactivity.

Authors:  Pål Johansen; Tazio Storni; Lorna Rettig; Zhiyong Qiu; Ani Der-Sarkissian; Kent A Smith; Vania Manolova; Karl S Lang; Gabriela Senti; Beat Müllhaupt; Tilman Gerlach; Roberto F Speck; Adrian Bot; Thomas M Kündig
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-24       Impact factor: 11.205

4.  Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus.

Authors:  C Burkhart; G Freer; R Castro; L Adorini; K H Wiesmüller; R M Zinkernagel; H Hengartner
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

5.  Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?

Authors:  M F Bachmann; T M Kündig; H Hengartner; R M Zinkernagel
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

6.  Immunogenicity of an aphthovirus chimera of the glycoprotein of vesicular stomatitis virus.

Authors:  P R Grigera; M Garcia-Briones; O Periolo; J L la Torre; R R Wagner
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

7.  Pre-clinical development of a vaccine against Lassa fever.

Authors:  L Banadyga; D R Stein; X Qiu; D Safronetz
Journal:  Can Commun Dis Rep       Date:  2018-06-07

8.  Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction.

Authors:  M F Bachmann; H Hengartner; R M Zinkernagel
Journal:  Med Microbiol Immunol       Date:  1994-12       Impact factor: 3.402

9.  Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses.

Authors:  M F Bachmann; T M Kündig; C P Kalberer; H Hengartner; R M Zinkernagel
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

10.  Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.

Authors:  U Steinhoff; U Müller; A Schertler; H Hengartner; M Aguet; R M Zinkernagel
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103
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