Literature DB >> 7684459

Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes.

C L Miller1, R Longnecker, E Kieff.   

Abstract

LMP2A is expressed in latent Epstein-Barr virus (EBV) infection and interacts with LMP1 and members of the src tyrosine kinase family in the plasma membrane. Since tyrosine kinase mediate receptor-induced changes in intracellular free calcium, the effect of LMP2A on receptor-mediated intracellular calcium mobilization was evaluated by stably expressing LMP2A in an EBV-negative Burkitt tumor cell line (BJAB) or in LMP1-converted BJAB cells. LMP2A significantly blocked calcium mobilization following class II, CD19, or immunoglobulin M cross-linking. LMP2A effects were partially reversed in LMP1-converted cell lines. These results are compatible with LMP2A acting in latent B-lymphocyte infection to downmodulate LMP1 effects on cell growth or to inhibit induction of lytic EBV infection in specific human tissues following receptor ligation.

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Year:  1993        PMID： 7684459      PMCID： PMC237645     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  50 in total

Review 1.  Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation.

Authors:  J C Cambier; L B Justement; M K Newell; Z Z Chen; L K Harris; V M Sandoval; M J Klemsz; J T Ransom
Journal:  Immunol Rev       Date:  1987-02       Impact factor: 12.988

2.  Two related Epstein-Barr virus membrane proteins are encoded by separate genes.

Authors:  J Sample; D Liebowitz; E Kieff
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

3.  Amplification of human B cell activation by a monoclonal antibody to the B cell-specific antigen CD22, Bp 130/140.

Authors:  A Pezzutto; B Dörken; G Moldenhauer; E A Clark
Journal:  J Immunol       Date:  1987-01-01       Impact factor: 5.422

4.  Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity.

Authors:  D Wang; D Liebowitz; F Wang; C Gregory; A Rickinson; R Larson; T Springer; E Kieff
Journal:  J Virol       Date:  1988-11       Impact factor: 5.103

5.  Expression of HLA-DR antigen in human class II mutant B-cell lines by double infection with retrovirus vectors.

Authors:  Z Yang; A J Korman; J Cooper; D Pious; R S Accolla; R C Mulligan; J L Strominger
Journal:  Mol Cell Biol       Date:  1987-11       Impact factor: 4.272

6.  Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.

Authors:  J A Ledbetter; P S Rabinovitch; C H June; C W Song; E A Clark; F M Uckun
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

7.  The truncated form of the Epstein-Barr virus latent-infection membrane protein expressed in virus replication does not transform rodent fibroblasts.

Authors:  D Wang; D Liebowitz; E Kieff
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

8.  Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus.

Authors:  V R Baichwal; B Sugden
Journal:  Oncogene       Date:  1988-05       Impact factor: 9.867

9.  Inositol phospholipid and intracellular calcium metabolism in B lymphocytes stimulated with antigen.

Authors:  K Partain; K Jensen; M Aldo-Benson
Journal:  Biochem Biophys Res Commun       Date:  1986-11-14       Impact factor: 3.575

10.  A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells.

Authors:  J Hombach; L Leclercq; A Radbruch; K Rajewsky; M Reth
Journal:  EMBO J       Date:  1988-11       Impact factor: 11.598
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  68 in total

Review 1.  Signaling activities of gammaherpesvirus membrane proteins.

Authors:  B Damania; J K Choi; J U Jung
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

2.  Epstein-barr virus (EBV) nuclear protein 2-induced disruption of EBV latency in the Burkitt's lymphoma cell line Akata: analysis by tetracycline-regulated expression.

Authors:  S Fujiwara; Y Nitadori; H Nakamura; T Nagaishi; Y Ono
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

3.  Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.

Authors:  F Scholle; K M Bendt; N Raab-Traub
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

4.  Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.

Authors:  R Swart; I K Ruf; J Sample; R Longnecker
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

5.  Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development.

Authors:  Toni Portis; Richard Longnecker
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

6.  Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.

Authors:  Marcel Pietrek; Melanie M Brinkmann; Ilona Glowacka; Anette Enlund; Anika Hävemeier; Oliver Dittrich-Breiholz; Michael Kracht; Marc Lewitzky; Kalle Saksela; Stephan M Feller; Thomas F Schulz
Journal:  J Virol       Date:  2010-06-09       Impact factor: 5.103

7.  Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.

Authors:  M Lagunoff; R Majeti; A Weiss; D Ganem
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

8.  An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

Authors:  C L Miller; J H Lee; E Kieff; R Longnecker
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

9.  Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus.

Authors:  H Lee; J Guo; M Li; J K Choi; M DeMaria; M Rosenzweig; J U Jung
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

Review 10.  Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.

Authors:  M A Nalesnik; T E Starzl
Journal:  Transplant Sci       Date:  1994-09
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