Literature DB >> 7684117

The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle.

R M Horton1, A A Manfredi, B M Conti-Tronconi.   

Abstract

We have PCR-amplified cDNA sequence of the "embryonic" gamma subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the gamma subunit in EOM mRNA, but not in control skeletal muscle. The presence of gamma subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the gamma subunit is generally present.

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Year:  1993        PMID： 7684117     DOI： 10.1212/wnl.43.5.983

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  18 in total

1.  Sparing of extraocular muscle in aging and muscular dystrophies: a myogenic precursor cell hypothesis.

Authors:  Kristen M Kallestad; Sadie L Hebert; Abby A McDonald; Mark L Daniel; Sharon R Cu; Linda K McLoon
Journal:  Exp Cell Res       Date:  2011-01-27       Impact factor: 3.905

2.  A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor.

Authors:  Russell W Teichert; Jean Rivier; Josep Torres; John Dykert; Charleen Miller; Baldomero M Olivera
Journal:  J Neurosci       Date:  2005-01-19       Impact factor: 6.167

Review 3.  The acetylcholine receptor ligand-gated channel as a molecular target of disease and therapeutic agents.

Authors:  F J Barrantes
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

4.  Do palisade endings in extraocular muscles arise from neurons in the motor nuclei?

Authors:  Karoline Lienbacher; Michael Mustari; Howard S Ying; Jean A Büttner-Ennever; Anja K E Horn
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-04-19       Impact factor: 4.799

5.  A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization.

Authors:  Linda K McLoon; Han Na Park; Jong-Hee Kim; Fatima Pedrosa-Domellöf; Ladora V Thompson
Journal:  J Appl Physiol (1985)       Date:  2011-07-21

6.  T helper cell recognition of muscle acetylcholine receptor in myasthenia gravis. Epitopes on the gamma and delta subunits.

Authors:  A A Manfredi; M P Protti; M W Dalton; J F Howard; B M Conti-Tronconi
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

7.  Continuous myofiber remodeling in uninjured extraocular myofibers: myonuclear turnover and evidence for apoptosis.

Authors:  Linda K McLoon; Jocelyn Rowe; Jonathan Wirtschafter; Kathleen M McCormick
Journal:  Muscle Nerve       Date:  2004-05       Impact factor: 3.217

8.  Activated satellite cells are present in uninjured extraocular muscles of mature mice.

Authors:  Linda K McLoon; Jonathan Wirtschafter
Journal:  Trans Am Ophthalmol Soc       Date:  2002

9.  Tyrosine-rich conopeptides affect voltage-gated K+ channels.

Authors:  Julita S Imperial; Ping Chen; Annett Sporning; Heinrich Terlau; Norelle L Daly; David J Craik; Paul F Alewood; Baldomero M Olivera
Journal:  J Biol Chem       Date:  2008-05-27       Impact factor: 5.157

10.  Epitopes on the beta subunit of human muscle acetylcholine receptor recognized by CD4+ cells of myasthenia gravis patients and healthy subjects.

Authors:  L Moiola; P Karachunski; M P Protti; J F Howard; B M Conti-Tronconi
Journal:  J Clin Invest       Date:  1994-03       Impact factor: 14.808
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