| Literature DB >> 7683936 |
P Kotovuori1, E Tontti, R Pigott, M Shepherd, M Kiso, A Hasegawa, R Renkonen, P Nortamo, D C Altieri, C G Gahmberg.
Abstract
Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.Entities:
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Year: 1993 PMID： 7683936 DOI： 10.1093/glycob/3.2.131
Source DB: PubMed Journal: Glycobiology ISSN： 0959-6658 Impact factor: 4.313