Literature DB >> 7683856

Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon.

M J Steiger1, G Tarnesby, S Gabe, J McLaughlin, A H Schapira.   

Abstract

The prognosis of patients with progressive multifocal leukoencephalopathy is poor, with few patients showing remission or surviving. We describe a 37-year-old man who developed progressive multifocal leukoencephalopathy in association with sarcoidosis. Despite treatment with cytarabine and acyclovir, he continued to deteriorate. Shortly following the addition of interferon alfa, he made a dramatic improvement, regaining full functional independence. The use of interferon alfa in addition to cytarabine in such patients offers a new therapeutic approach worthy of further trial.

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Year:  1993        PMID： 7683856     DOI： 10.1002/ana.410330415

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  11 in total

1.  Progressive Multifocal Leukoencephalopathy.

Authors: 
Journal:  Curr Treat Options Neurol       Date:  2000-07       Impact factor: 3.598

2.  Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy.

Authors:  Juliene K G Co; Saguna Verma; Ulziijargal Gurjav; Laarni Sumibcay; Vivek R Nerurkar
Journal:  J Infect Dis       Date:  2007-07-20       Impact factor: 5.226

Review 3.  Progressive multifocal leukoencephalopathy.

Authors:  Joseph R Berger
Journal:  Curr Neurol Neurosci Rep       Date:  2007-11       Impact factor: 5.081

4.  Progressive multifocal leukoencephalopathy in AIDS: are there any MR findings useful to patient management and predictive of patient survival? AIDS Clinical Trials Group, 243 Team.

Authors:  M J Post; C Yiannoutsos; D Simpson; J Booss; D B Clifford; B Cohen; J C McArthur; C D Hall
Journal:  AJNR Am J Neuroradiol       Date:  1999 Nov-Dec       Impact factor: 3.825

5.  Activities of various compounds against murine and primate polyomaviruses.

Authors:  G Andrei; R Snoeck; M Vandeputte; E De Clercq
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

Review 6.  Natalizumab and progressive multifocal leucoencephalopathy.

Authors:  J R Berger
Journal:  Ann Rheum Dis       Date:  2006-11       Impact factor: 19.103

7.  Treatment of non-AIDS progressive multifocal leukoencephalopathy with cytosine arabinoside.

Authors:  A J Aksamit
Journal:  J Neurovirol       Date:  2001-08       Impact factor: 2.643

Review 8.  Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy.

Authors:  Leslie J Marshall; Eugene O Major
Journal:  J Neuroimmune Pharmacol       Date:  2010-04-17       Impact factor: 4.147

Review 9.  Transgenic models for cytokine-induced neurological disease.

Authors:  Iain L Campbell; Markus J Hofer; Axel Pagenstecher
Journal:  Biochim Biophys Acta       Date:  2009-10-14

10.  Progressive multifocal leukoencephalopathy.

Authors:  Allen J Aksamit
Journal:  Curr Treat Options Neurol       Date:  2008-05       Impact factor: 3.598
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