Literature DB >> 7683279

Irsogladine is a potent inhibitor of angiogenesis.

Y Sato1, A Morimoto, A Kiue, K Okamura, R Hamanaka, K Kohno, M Kuwano, T Sakata.   

Abstract

We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

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Year:  1993        PMID： 7683279     DOI： 10.1016/0014-5793(93)81558-h

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

Review 1.  Mechanisms of tumor angiogenesis and therapeutic implications: angiogenesis inhibitors.

Authors:  H Malonne; I Langer; R Kiss; G Atassi
Journal:  Clin Exp Metastasis       Date:  1999-02       Impact factor: 5.150

2.  Up-regulation of urokinase-type plasminogen activator and its receptor correlates with enhanced invasion activity of human glioma cells mediated by transforming growth factor-alpha or basic fibroblast growth factor.

Authors:  T Mori; T Abe; Y Wakabayashi; T Hikawa; K Matsuo; Y Yamada; M Kuwano; S Hori
Journal:  J Neurooncol       Date:  2000       Impact factor: 4.130

3.  Suppressing effects of 6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine and related synthetic compounds on azoxymethane-induced aberrant crypt foci in rat colon.

Authors:  Y Hirose; T Tanaka; H Makita; M Yang; K Satoh; A Hara; M Maeda; H B Toriyama; H Mori; H Tsuda
Journal:  Jpn J Cancer Res       Date:  1996-06

4.  Triazine derivatives inhibit rat hepatocarcinogenesis but do not enhance gap junctional intercellular communication.

Authors:  T Hori; M Asamoto; V Krutovskikh; Y Iwahori; M Maeda; H Toriyama-Baba; N Takasuka; H Tsuda
Journal:  Jpn J Cancer Res       Date:  1997-01

5.  Clotrimazole, an imidazole antimycotic, is a potent inhibitor of angiogenesis.

Authors:  H Takahashi; M Abe; T Sugawara; K Tanaka; Y Saito; S Fujimura; M Shibuya; Y Sato
Journal:  Jpn J Cancer Res       Date:  1998-04

6.  Suppressive effect of irsogladine maleate on diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in male F344 rats.

Authors:  S Sugie; K Okamoto; F Ueda; T Watanabe; T Tanaka; H Mori
Journal:  Jpn J Cancer Res       Date:  1998-04
  6 in total

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