| Literature DB >> 7682736 |
G Opelz1, J Mytilineos, S Scherer, H Dunckley, J Trejaut, J Chapman, G Fischer, I Fae, D Middleton, D Savage.
Abstract
The effect of matching for HLA-DR antigens was analyzed retrospectively in 3455 cadaver kidney transplants that were typed by the DNA-RFLP method. HLA-DR matching improved the one-year graft survival rate significantly (P < 0.01). Importantly, in 718 first transplants in which the number of mismatches assigned by serological typing was different from that assigned by DNA typing, only the DNA results showed a significant impact of matching on graft outcome (P = 0.03). These results demonstrate that DNA typing is clinically relevant. We were unable to confirm that the HLA-DR6 specificity or the DR6-split DRB1*1302 are associated with poor graft survival.Entities:
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Year: 1993 PMID： 7682736
Source DB: PubMed Journal: Transplantation ISSN： 0041-1337 Impact factor: 4.939