The possible role of angiogenesis in the metastatic potential of human melanoma. Clinicopathological aspects.

In this review, we present a literature survey of angiogenesis in melanoma. Progression in melanoma is supposed to be associated with an angiogenic response. Several histological studies have shown an increase of vascular structures in malignant melanoma, which is not the case in common naevocellular naevi. Neovascularization can be caused by several angiogenic factors: the most important of those produced in melanoma are described. Proteases such as urokinase plasminogen activator and metalloproteinases are important for the migration for both endothelial cells and tumour cells. Possible effects of these factors in melanoma cells are discussed. Finally, inhibition of angiogenesis and its potential role in melanoma therapy are considered.