Literature DB >> 7682103

Telomeric associations and loss of telomeric DNA repeats in renal tumors.

K Holzmann1, N Blin, C Welter, K D Zang, G Seitz, W Henn.   

Abstract

In a series of cytogenetically analyzed renal tumors of different histological types (chromophobe carcinoma, clear-cell carcinoma, chromophilic carcinoma, and oncocytoma) and normal renal tissue, the length of the telomeric DNA repeats was assessed using a (TTAGGG)3 oligonucleotide probe. A strong correlation was noted between pronounced telomere shortening and the appearance of telomeric associations of chromosomes. These data suggest an etiologic role of the loss of telomeric DNA repeats in the formation of telomeric associations and a possible involvement of this mechanism in the pathogenesis of chromosome aberrations in human tumors.

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Year:  1993        PMID： 7682103     DOI： 10.1002/gcc.2870060308

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  8 in total

1.  Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.

Authors:  E M Rogan; T M Bryan; B Hukku; K Maclean; A C Chang; E L Moy; A Englezou; S G Warneford; L Dalla-Pozza; R R Reddel
Journal:  Mol Cell Biol       Date:  1995-09       Impact factor: 4.272

Review 2.  Activation of telomerase in a human tumor.

Authors:  T de Lange
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

3.  Telomerase activity: a biomarker of cell proliferation, not malignant transformation.

Authors:  C D Belair; T R Yeager; P M Lopez; C A Reznikoff
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

4.  Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines.

Authors:  C Strahl; E H Blackburn
Journal:  Mol Cell Biol       Date:  1996-01       Impact factor: 4.272

5.  Telomerase activity in human ovarian carcinoma.

Authors:  C M Counter; H W Hirte; S Bacchetti; C B Harley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

6.  Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays.

Authors:  Meng Chen; Yuanqing Ye; Hushan Yang; Pheroze Tamboli; Surena Matin; Nizar M Tannir; Christopher G Wood; Jian Gu; Xifeng Wu
Journal:  Int J Cancer       Date:  2009-11-15       Impact factor: 7.396

7.  Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas.

Authors:  D Gisselsson; L Gorunova; M Höglund; N Mandahl; P Elfving
Journal:  Br J Cancer       Date:  2004-07-19       Impact factor: 7.640

8.  Telomere reduction of specific chromosome translocation in acute myelocytic leukemia.

Authors:  K Takauchi; S Tashiro; M Ohtaki; N Kamada
Journal:  Jpn J Cancer Res       Date:  1994-02
  8 in total

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