Literature DB >> 7682059

In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.

F Liao1, H S Shin, S G Rhee.   

Abstract

The phosphorylation of purified phospholipase C-gamma 1 (PLC-gamma 1) and PLC-gamma 2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-gamma 1 and PLC-gamma 2, suggesting that both PLC-gamma isozymes can be phosphorylated in cells by any of the src-family PTKs in response to the activation of cell surface receptors. Comparison of the in vitro phosphorylation rates revealed no distinct specificity between PLC-gamma 1 and PLC-gamma 2, or between the five PTKs.

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Year:  1993        PMID： 7682059     DOI： 10.1006/bbrc.1993.1320

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  21 in total

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Authors:  Taku Iwamoto; Nori Mamiya; Shoichi Masushige; Satoshi Kida
Journal:  Cytotechnology       Date:  2005-01       Impact factor: 2.058

2.  Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion.

Authors:  Hiroshi Nozawa; Gina Howell; Shinsuke Suzuki; Qing Zhang; Yanjun Qi; Judith Klein-Seetharaman; Alan Wells; Jennifer R Grandis; Sufi M Thomas
Journal:  Clin Cancer Res       Date:  2008-07-01       Impact factor: 12.531

Review 3.  The role of tyrosine phosphorylation in angiotensin II mediated intracellular signaling and cell growth.

Authors:  B Schieffer; K E Bernstein; M B Marrero
Journal:  J Mol Med (Berl)       Date:  1996-02       Impact factor: 4.599

4.  Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.

Authors:  C L Law; K A Chandran; S P Sidorenko; E A Clark
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

5.  1,25 dihydroxyvitamin D3 stimulates phospholipase C-gamma in rat colonocytes: role of c-Src in PLC-gamma activation.

Authors:  S Khare; M J Bolt; R K Wali; S F Skarosi; H K Roy; S Niedziela; B Scaglione-Sewell; B Aquino; C Abraham; M D Sitrin; T A Brasitus; M Bissonnette
Journal:  J Clin Invest       Date:  1997-04-15       Impact factor: 14.808

6.  CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice.

Authors:  Mehmet Hakan Ozdener; Selvakumar Subramaniam; Sinju Sundaresan; Omar Sery; Toshihiro Hashimoto; Yoshinori Asakawa; Philippe Besnard; Nada A Abumrad; Naim Akhtar Khan
Journal:  Gastroenterology       Date:  2014-01-09       Impact factor: 22.682

7.  Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Authors:  K Hansen; M Johnell; A Siegbahn; C Rorsman; U Engström; C Wernstedt; C H Heldin; L Rönnstrand
Journal:  EMBO J       Date:  1996-10-01       Impact factor: 11.598

8.  The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1.

Authors:  M Valius; J P Secrist; A Kazlauskas
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

9.  Cyclosporin A, FK506 and dithranol after tyrosine-specific protein phosphorylation in HaCaT keratinocytes.

Authors:  H M Ockenfels; G Nussbaum; T Schultewolter; P M Burger; M Goos
Journal:  Arch Dermatol Res       Date:  1995       Impact factor: 3.017

10.  Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro.

Authors:  Anastacia M Garcia; Stephanie J Nakano; Anis Karimpour-Fard; Karin Nunley; Penny Blain-Nelson; Natalie M Stafford; Brian L Stauffer; Carmen C Sucharov; Shelley D Miyamoto
Journal:  Circ Heart Fail       Date:  2018-09       Impact factor: 8.790
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