Literature DB >> 7681712

Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells.

K Okita1, Q Li, T Murakamio, M Takahashi.   

Abstract

The present study was undertaken to investigate the effects and the mechanism of the components of Sho-saiko-to (baicalein, baicalin, saikosaponin-a, saikosaponin-c, ginsenoside Rb1, ginsenoside Rg1) on cultured human hepatoma cells (HuH-7). Cell cycle analysis was carried out with flow cytometry and the bromodeoxyuridine (BrdU)-labelling method. The results showed that baicalein, baicalin and saikosaponin-a inhibited cell proliferation dose-dependently but independently of the cell cycle. Furthermore, it was found that saikosaponin-a possesses a strong cell-killing effect. On the other hand, saikosaponin-c, ginsenoside Rb1 and ginsenoside Rg1 had no effect on cell proliferation.

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Year:  1993        PMID： 7681712     DOI： 10.1097/00008469-199303000-00010

Source DB:  PubMed          Journal:  Eur J Cancer Prev        ISSN： 0959-8278            Impact factor:   2.497


  8 in total

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Authors:  S Chen; Q Ruan; E Bedner; A Deptala; X Wang; T C Hsieh; F Traganos; Z Darzynkiewicz
Journal:  Cell Prolif       Date:  2001-10       Impact factor: 6.831

2.  Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis.

Authors:  Lin Ye; Yongning Jia; K E Ji; Andrew J Sanders; Kan Xue; Jiafu Ji; Malcolm D Mason; Wen G Jiang
Journal:  Oncol Lett       Date:  2015-07-06       Impact factor: 2.967

3.  Herbal medicine and hepatocellular carcinoma: applications and challenges.

Authors:  Yan Li; Robert C G Martin
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-20       Impact factor: 2.629

Review 4.  Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.

Authors:  Hendrik Fuchs; Nicole Niesler; Alexandra Trautner; Simko Sama; Gerold Jerz; Hossein Panjideh; Alexander Weng
Journal:  Biomedicines       Date:  2017-03-29

Review 5.  Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine.

Authors:  Nobuhiro Ohtake; Yoichiro Nakai; Masahiro Yamamoto; Iwao Sakakibara; Shuichi Takeda; Sakae Amagaya; Masaki Aburada
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2004-12-05       Impact factor: 3.205

6.  Baicalein induces apoptosis and autophagy via endoplasmic reticulum stress in hepatocellular carcinoma cells.

Authors:  Zhongxia Wang; Chunping Jiang; Weibo Chen; Guang Zhang; Dongjun Luo; Yin Cao; Junhua Wu; Yitao Ding; Baorui Liu
Journal:  Biomed Res Int       Date:  2014-06-03       Impact factor: 3.411

7.  Cell death induced by baicalein in human hepatocellular carcinoma cell lines.

Authors:  Y Matsuzaki; N Kurokawa; S Terai; Y Matsumura; N Kobayashi; K Okita
Journal:  Jpn J Cancer Res       Date:  1996-02

8.  The Effect of Transarterial Chemoembolization in Combination With Kang'ai Injection on Patients With Intermediate Stage Hepatocellular Carcinoma: A Prospective Study.

Authors:  Yue-Meng Wan; Yu-Hua Li; Zhi-Yuan Xu; Hua-Mei Wu; Ying Xu; Mei Yang; Xi-Nan Wu
Journal:  Integr Cancer Ther       Date:  2017-11-07       Impact factor: 3.279
  8 in total

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